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亚硒酸钠和维生素E在维生素D过多症中的保护作用

[The protective effect of sodium selenite and vitamin E in hypervitaminosis D].

作者信息

Sokolova S V, Spirichev V B, Kudrin A N

出版信息

Farmakol Toksikol. 1977 Jan-Feb;40(1):67-9.

PMID:300690
Abstract

Vitamin D2 (160 000-240 000 IU/kg) produced during 5 days pronounced hypercalciemia and metastatic calcification of internal organs. Subcutaneous injection of sodium selenite (10 mg/kg) brought down the level of calcium in the blood plasma and decreased calcification of internal organs. Conjoint introduction of sodium selenite (30 gamma/kg) and of vitamin "E" (50 mg/kg) lowered the aortal calcinosis by 54 per cent, of the lung--by 93, of the heart--by 86 and of the kidney--by 96 per cent.

摘要

维生素D2(160000 - 240000国际单位/千克)连续5天使用会导致明显的高钙血症和内脏转移性钙化。皮下注射亚硒酸钠(10毫克/千克)可降低血浆钙水平并减少内脏钙化。联合注射亚硒酸钠(30微克/千克)和维生素“E”(50毫克/千克)可使主动脉钙化降低54%,肺部钙化降低93%,心脏钙化降低86%,肾脏钙化降低96%。

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