Olshan A F
Cancer Genet Cytogenet. 1986 Apr 15;21(4):303-7. doi: 10.1016/0165-4608(86)90209-8.
A hypothesis is advanced suggesting that the association between high birthweight, overgrowth features of certain congenital malformations, and Wilms' tumor may be due to the action of loci in addition to the putative Wilms' tumor locus on the short arm of chromosome #11. These genes include insulin, insulin-like growth factor II and the c-Ha-ras 1 oncogene. The possible role of environmental factors in the oncogenesis of Wilms' tumor is discussed.
一种假说被提出，认为高出生体重、某些先天性畸形的过度生长特征与威尔姆斯瘤之间的关联可能是由于除了位于11号染色体短臂上假定的威尔姆斯瘤基因座之外的其他基因座的作用。这些基因包括胰岛素、胰岛素样生长因子II和c-Ha-ras 1癌基因。文中还讨论了环境因素在威尔姆斯瘤肿瘤发生中的可能作用。
