King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2018 Aug;22(15):4956-4961. doi: 10.26355/eurrev_201808_15635.
Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss the epidemiology, pathogenesis and clinical appearances of MERS-CoV infections.
We conducted a broad search of the English-language literature in "PubMed" "Medline" "Web of knowledge", "EMBASE" and "Google Scholar" World Health Organization-WHO" using the key words "Middle East Respiratory Syndrome", "MERS", "MERS-CoV" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed the literature on epidemiology, pathogenesis and clinical appearances of MERS-CoV infection and the required information was documented.
The global prevalence of MERS-CoV infection from June 2012 to April 2018 is 2206 people. The number of cases reported from Saudi Arabia is 1831 (83%) with mortality rate of 787 (35.67%). The main clinical manifestations are fever, chills, generalized myalgia, cough, shortness of breath, nausea, vomiting and diarrhea. The age-allied prevalence of MERS-CoV was highest amongst elderly people with chronic debilitating diseases such as pulmonary diseases, end-stage renal illness, diabetes mellitus and malignancy.
MERS-CoV infection is an emerging global health concern, affected people in 27 countries in the various continents. MERS-CoV infection has been identified mainly in the Middle East, Europe, Africa, Asia and North America. Early detection and management of MERS-CoV infection is of critical importance to minimize the burden of the disease.
中东呼吸综合征冠状病毒（MERS-CoV）感染是一场正在全球蔓延的卫生危机。这种疾病的早期诊断和治疗仍然是一个主要挑战。本研究旨在讨论 MERS-CoV 感染的流行病学、发病机制和临床特征。
我们在“PubMed”“Medline”“Web of knowledge”“EMBASE”和“Google Scholar”以及世界卫生组织（WHO）的英文文献中进行了广泛搜索，使用的关键词是“中东呼吸综合征”、“MERS”、“MERS-CoV”、“流行病学”、“传播”、“发病机制”、“临床特征”。我们回顾了 MERS-CoV 感染的流行病学、发病机制和临床特征的文献，并记录了所需的信息。
自 2012 年 6 月至 2018 年 4 月，全球 MERS-CoV 感染的患病率为 2206 人。来自沙特阿拉伯的报告病例数为 1831 例（83%），死亡率为 787 例（35.67%）。主要临床表现为发热、寒战、全身肌痛、咳嗽、呼吸急促、恶心、呕吐和腹泻。MERS-CoV 与年龄相关的患病率在患有肺部疾病、终末期肾病、糖尿病和恶性肿瘤等慢性消耗性疾病的老年人中最高。
MERS-CoV 感染是一个新出现的全球卫生问题，影响了各大洲 27 个国家的人群。MERS-CoV 感染主要发生在中东、欧洲、非洲、亚洲和北美。早期发现和管理 MERS-CoV 感染对于减轻疾病负担至关重要。
