McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.
McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.
Prog Mol Biol Transl Sci. 2018;158:255-272. doi: 10.1016/bs.pmbts.2018.04.004. Epub 2018 May 29.
Major depressive disorder is a chronic and debilitating illness. It is most commonly treated with antidepressant drugs, however, as the majority of patients do not respond on their first trial or following several adequate trials, there is great interest in identifying biological factors that may help select the most appropriate treatment for each patient and in understanding biological processes that mediate treatment response. Epigenetic factors, such as non-coding RNAs (ncRNAs), hold potential as biomarkers of antidepressant response. In this chapter, we review key methodological considerations when investigating ncRNA biomarkers, including biological samples and technologies which have been used in these studies. Secondly, we summarize findings from studies investigating ncRNAs in antidepressant treatment response. Finally, we discuss some of the future directions which will be necessary for the development of clinically relevant epigenetic tools.
重度抑郁症是一种慢性且使人虚弱的疾病。它最常通过抗抑郁药物进行治疗，然而，由于大多数患者在首次尝试或经过几次充分的尝试后没有反应，因此人们非常感兴趣的是确定可能有助于为每个患者选择最合适的治疗方法的生物学因素，并了解介导治疗反应的生物学过程。表观遗传因素，如非编码 RNA(ncRNA)，可能成为抗抑郁反应的生物标志物。在本章中，我们回顾了在研究 ncRNA 生物标志物时需要考虑的关键方法学问题，包括已用于这些研究的生物样本和技术。其次，我们总结了关于 ncRNA 在抗抑郁治疗反应中的研究结果。最后，我们讨论了开发临床相关表观遗传工具所需的一些未来方向。
