二级和三级少突胶质细胞瘤和星形细胞瘤。
Grade II and III Oligodendroglioma and Astrocytoma.
机构信息
Brain Tumor Center, Erasmus MC Cancer Institute, Groene Hilledijk 301, Rotterdam 3075EA, The Netherlands.
Department of Neurosurgery, University of California, San Francisco, Box 0112, 505 Parnassus Avenue M779, San Francisco, CA 94143, USA.
出版信息
Neurol Clin. 2018 Aug;36(3):467-484. doi: 10.1016/j.ncl.2018.04.005. Epub 2018 Jun 15.
In the 2016 WHO classification of diffuse glioma, the diagnosis of an (anaplastic) oligodendroglioma requires the presence of both an IDH mutation (mt) and 1p/19q codeletion, whereas (anaplastic) astrocytoma are divided in IDH wild-type and IDHmt tumors. Standard of care for grade II and III glioma consists of resection. For patients with tumors that require postoperative treatment, radiotherapy and chemotherapy are recommended. Trials in newly diagnosed grade II and III glioma have shown survival benefit of the addition of chemotherapy to radiotherapy compared with initial treatment with radiotherapy alone; both temozolomide and PCV have been shown to improve survival.
在 2016 年世界卫生组织弥漫性胶质瘤分类中，（间变性）少突胶质细胞瘤的诊断需要同时存在 IDH 突变（mt）和 1p/19q 联合缺失，而（间变性）星形细胞瘤则分为 IDH 野生型和 IDHmt 肿瘤。二级和三级胶质瘤的标准治疗包括切除。对于需要术后治疗的患者，推荐放疗和化疗。新诊断的二级和三级胶质瘤的临床试验表明，与单独放疗相比，化疗联合放疗可提高生存率；替莫唑胺和 PCV 均已显示可改善生存。
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