Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Neurol Clin. 2018 Aug;36(3):517-532. doi: 10.1016/j.ncl.2018.04.008.
Primary central nervous system lymphoma (PCNSL) is an aggressive form of non-Hodgkin lymphoma restricted to the central nervous system. Stereotactic biopsy is the gold-standard for diagnosis of PCNSL. Extent of disease evaluation for newly diagnosed PCNSL patients includes brain imaging, eye examination, cerebrospinal fluid assessment, body imaging, and bone marrow biopsy. Methotrexate-based chemotherapy is the standard induction for PCNSL patients. Optimal consolidation therapy for PCNSL has not been defined, with several options feasible, including chemotherapy, high-dose chemotherapy, and autologous stem cell transplantation or whole-brain radiation therapy. Optimal treatment for relapsed and refractory PCNSL has not been defined.
原发性中枢神经系统淋巴瘤（PCNSL）是一种侵袭性非霍奇金淋巴瘤，局限于中枢神经系统。立体定向活检是 PCNSL 的金标准诊断方法。新诊断的 PCNSL 患者的疾病程度评估包括脑成像、眼部检查、脑脊液评估、全身成像和骨髓活检。甲氨蝶呤为基础的化疗是 PCNSL 患者的标准诱导治疗。PCNSL 的最佳巩固治疗尚未确定，有几种可行的选择，包括化疗、大剂量化疗以及自体干细胞移植或全脑放疗。复发性和难治性 PCNSL 的最佳治疗方法尚未确定。
