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信使核糖核酸的HLA - DQα长度多态性与血清学定义的特异性（DQw1、DRw53、DR3 + 5）之间的相关性

Correlation between an HLA-DQ alpha length polymorphism of messenger RNA and serologically defined specificities (DQw1, DRw53, DR3+5).

作者信息

Loiseau P, Lehn P, Dautry F, Lepage V, Colombani J, Cohen D, Dausset J, Degos L

出版信息

Immunogenetics. 1986;23(2):111-4. doi: 10.1007/BF00377970.

DOI:10.1007/BF00377970
PMID:3007342
Abstract

mRNAs for the two chains of the HLA-DQ molecule were analyzed, in particular the DQ alpha mRNA whose polymorphism had previously been suggested (Schenning et al. 1984). Northern blot transfers of the mRNA of 12 LCLs and of B lymphocytes from a healthy donor were carried out. We report that a length polymorphism of DQ alpha mRNA exists, and we show that it can be correlated with serologically defined specificities (DQw1, DRw53, DR3+5). This correlation could be explained by a linkage disequilibrium, as these specificities are considered to be different from those carried by the DQ molecule (except for the DQw1 specificity).

摘要

对HLA - DQ分子两条链的信使核糖核酸（mRNA）进行了分析，特别是对之前已有人提出其多态性的DQα mRNA（申宁等人，1984年）进行了分析。对12个淋巴母细胞系（LCL）以及一名健康供体的B淋巴细胞的mRNA进行了Northern印迹转移。我们报告称DQα mRNA存在长度多态性，并且我们表明它可与血清学定义的特异性（DQw1、DRw53、DR3 + 5）相关联。这种相关性可以用连锁不平衡来解释，因为这些特异性被认为与DQ分子所携带的特异性不同（除了DQw1特异性）。

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Immunogenetics. 1986;23(2):111-4. doi: 10.1007/BF00377970.
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本文引用的文献

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Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis.通过二维凝胶电泳证明存在第三条结构上不同的人Iaβ链。
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Unequal crossover generates variation in ubiquitin coding unit number at the human UbC polyubiquitin locus.
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Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.HLA-DC Ⅱ类组织相容性抗原的α链和β链在其氨基末端结构域均表现出广泛的多态性。
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7
Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.人类6号染色体上与HLA - DRα链相关的序列：用DCα链探针检测到的限制性内切酶多态性
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1972-6. doi: 10.1073/pnas.80.7.1972.
8
Biochemical and functional evidence that an MT3 supertypic determinant defined by a monoclonal antibody is carried on the DR molecule on HLA-DR7 cell lines.由单克隆抗体定义的MT3超型决定簇存在于HLA - DR7细胞系的DR分子上的生化和功能证据。
J Immunol. 1984 Dec;133(6):3195-202.
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Serologically detectable polymorphism of the HLA-DC alpha-subunit.HLA-DC α亚基的血清学可检测多态性。
J Immunol. 1984 Jan;132(1):277-82.
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Identification of the MT3 molecule using two-dimensional gel electrophoresis and alloantisera.利用二维凝胶电泳和同种异体抗血清鉴定MT3分子。
Immunogenetics. 1983;18(6):575-83. doi: 10.1007/BF00345965.