通过二维凝胶电泳证明存在第三条结构上不同的人Iaβ链。
Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis.
作者信息
Karr R W, Kannapell C C, Stein J A, Fuller T C, Duquesnoy R J, Rodey G E, Mann D L, Gebel H M, Schwartz B D
出版信息
J Exp Med. 1982 Aug 1;156(2):652-7. doi: 10.1084/jem.156.2.652.
Abstract
Previous studies have indicated that HLA-DR homozygous cell lines express two Ia alpha and Ia beta chains that combine to form at least two Ia molecules. This report demonstrates by two-dimensional gel electrophoresis the existence of a third structurally distinct human Ia beta chain on DR2 and DR5 cell lines. This suggests that at least five separate genes control the expression of Ia molecules on HLA-DR homozygous cell lines.
摘要
先前的研究表明，HLA - DR纯合细胞系表达两条Iaα链和Iaβ链，它们结合形成至少两种Ia分子。本报告通过二维凝胶电泳证明，在DR2和DR5细胞系上存在第三条结构不同的人Iaβ链。这表明至少有五个独立的基因控制HLA - DR纯合细胞系上Ia分子的表达。
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