金灯藤全草的化学成分。
Chemical Constituents from the Whole Plant of Cuscuta reflexa.
作者信息
Aung Tin Thu Thu, Xia Meng-Yuan, Hein Pyae Phyo, Tang Rong, Zhang Dong-Dong, Yang Jun, Yang Xue-Fei, Hu Dong-Bao, Wang Yue-Hu
机构信息
Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2020 Oct;10(5):337-344. doi: 10.1007/s13659-020-00265-x. Epub 2020 Sep 21.
Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4-15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA.
从采自缅甸的菟丝子（旋花科）全草中分离得到两个新的2H-吡喃-2-酮葡萄糖苷，即菟丝子苷A（1）和B（2），以及一个新的甾体葡萄糖苷，7β-甲氧基-β-谷甾醇3-O-β-D-吡喃葡萄糖苷（3），同时还得到12个已知化合物（4 - 15）。通过广泛的光谱分析确定了这些新化合物的化学结构。利用猪胰脂肪酶（PPL）评估了这些分离物的抗肥胖活性，并使用凝血酶、血小板活化因子（PAF）、花生四烯酸（AA）或胶原蛋白诱导的兔血小板筛选了抗血小板聚集活性。7β-甲氧基-β-谷甾醇3-O-β-D-吡喃葡萄糖苷（3）表现出较弱的PPL抑制活性。菟丝子苷A（1）、其乙酰化衍生物（1a）和苦玄参苷B（8）对胶原蛋白诱导的兔血小板聚集表现出较弱的抑制活性。化合物1a对AA诱导的兔血小板聚集也表现出抑制活性。
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