Tang Rong, Zhang Ya-Qiong, Hu Dong-Bao, Yang Xue-Fei, Yang Jun, San Myint Myint, Oo Thaung Naing, Kong Yi, Wang Yue-Hu
Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Nat Prod Bioprospect. 2019 Jun;9(3):231-241. doi: 10.1007/s13659-019-0208-z. Epub 2019 May 9.
Two new amides (E)-N-cinnamoyl-2-methoxypiperidine (1) and (R)-1-(2-oxopyrrolidin-3-yl)-5,6-dihydropyridin-2(1H)-one (2), four new amide glucosides, retrofractosides A-D (3-6), and two new phenylpropanoid glucosides, retrofractosides E (7) and F (8), together with 24 known compounds (9-32) were isolated from the fruits of Piper retrofractum. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. All of these isolates (1-32) were evaluated for inhibitory activity against mouse platelet aggregation induced by the peptide AYPGKF-NH. (E)-N-(Tetrahydro-2H-pyran-2-yl)cinnamamide (9) showed a weak inhibitory effect, with an inhibition ratio of 52.0% at a concentration of 150 μM.
从蒌叶果实中分离得到两个新酰胺类化合物（E）-N-肉桂酰基-2-甲氧基哌啶（1）和（R）-1-（2-氧代吡咯烷-3-基）-5,6-二氢吡啶-2（1H）-酮（2）、四个新酰胺葡萄糖苷类化合物，即反折蒌叶苷A-D（3-6）、两个新苯丙素苷类化合物，即反折蒌叶苷E（7）和F（8），以及24个已知化合物（9-32）。通过广泛的光谱分析阐明了这些新化合物的化学结构。对所有这些分离物（1-32）进行了抗肽AYPGKF-NH诱导的小鼠血小板聚集抑制活性评价。（E）-N-（四氢-2H-吡喃-2-基）肉桂酰胺（9）显示出较弱的抑制作用，在浓度为150μM时抑制率为52.0%。
