Department of Medical Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Department of Anatomy, Faculty of medicine, Tehran university of medical sciences, Tehran, Iran; Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
J Cell Biochem. 2018 Nov;119(11):8723-8736. doi: 10.1002/jcb.27202. Epub 2018 Aug 3.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such as encoding nerve growth factor, APOE, and glial cell-derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，与记忆、思维、语言和推理能力的损害有关。尽管针对 AD 的治疗进行了广泛的研究，但持久和完全缓解的情况很少见。因此，需要新的治疗方法。在各种治疗方法中，干细胞（即神经干细胞、间充质干细胞和胚胎干细胞）和保护性基因的传递，如编码神经生长因子、APOE 和胶质细胞源性神经营养因子，在 AD 治疗中显示出了希望。在这里，我们总结了 AD 治疗中各种有效的治疗方法（即干细胞和基因）。
