Zahedipour Fatemeh, Hosseini Seyede Atefe, Henney Neil C, Barreto George E, Sahebkar Amirhossein
Department of Medical Biotechnology, School of Medicine; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
Neural Regen Res. 2022 Aug;17(8):1675-1684. doi: 10.4103/1673-5374.332128.
Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders. Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many other neurodegenerative diseases. Therefore, a potent proinflammatory/proapoptotic tumor necrosis factor alpha could be a strong candidate for targeted therapy. Plant derivatives have now become promising candidates as therapeutic agents because of their antioxidant and chemical characteristics, and anti-inflammatory features. Recently, phytochemicals including flavonoids, terpenoids, alkaloids, and lignans have generated interest as tumor necrosis factor alpha inhibitor candidates for a number of diseases involving inflammation within the nervous system. In this review, we discuss how phytochemicals as tumor necrosis factor alpha inhibitors are a therapeutic strategy targeting neurodegeneration.
炎症过程和促炎细胞因子在神经退行性疾病的细胞过程中起关键作用，并与功能和精神健康障碍的发病机制相关。据报道，肿瘤坏死因子α在阿尔茨海默病、帕金森病、肌萎缩侧索硬化症以及许多其他神经退行性疾病的中枢神经系统中起主要作用。因此，一种强效的促炎/促凋亡肿瘤坏死因子α可能是靶向治疗的有力候选物。由于植物衍生物具有抗氧化、化学特性和抗炎特性，它们现已成为有前景的治疗药物候选物。最近，包括黄酮类化合物、萜类化合物、生物碱和木脂素在内的植物化学物质，作为涉及神经系统炎症的多种疾病的肿瘤坏死因子α抑制剂候选物而受到关注。在这篇综述中，我们讨论了植物化学物质作为肿瘤坏死因子α抑制剂如何成为一种针对神经退行性变的治疗策略。
