Brackertz D, Mitchell G F, Vadas M A, Mackay I R
J Immunol. 1977 May;118(5):1645-8.
Antigen-induced arthritis in mice occurs after immunization and subsequent intraarticular challenge with methylated bovine serum albumin (mBSA). In adoptive transfer experiments, susceptible C57BL mice and resistant CBA mice were compared in their capacity to express delayed-type hypersensitivity (DTH) by ear assay, and to express arthritis. The expression of DTH could be transferred incrementally by lymphoid cells in C57BL mice, but not in CBA mice. Both immune lymphoid cells and, to a much lesser extent, serum transferred the capacity to develop arthritis in C57BL mice. The reactivity of transferred cells was abolished by anti-Thy-1 but enhanced by enrichment for T cells with anti-immunoglobulin columns. If this model disease can be equated with human rheumatoid synovitis, the lesions in the human disease would be an expression of a T cell-dependent activity.
小鼠抗原诱导性关节炎发生于用甲基化牛血清白蛋白（mBSA）免疫并随后进行关节内攻击之后。在过继转移实验中，对易感性C57BL小鼠和抗性CBA小鼠通过耳部试验表达迟发型超敏反应（DTH）以及表达关节炎的能力进行了比较。C57BL小鼠的DTH表达可通过淋巴细胞递增转移，但CBA小鼠不行。免疫淋巴细胞以及在小得多的程度上血清均可转移C57BL小鼠发生关节炎的能力。转移细胞的反应性被抗Thy-1消除，但通过用抗免疫球蛋白柱富集T细胞而增强。如果这种模型疾病可等同于人类类风湿性滑膜炎，那么人类疾病中的病变将是T细胞依赖性活性的一种表现。
