职业性哮喘与环氧树脂。

Occupational Asthma From Epoxy Compounds.

机构信息

Finnish Institute of Occupational Health, Helsinki, Finland.

Fundación Jiménez Díaz, Department of Allergy, Department of Medicine, Universidad Autónoma de Madrid, CIBERES, Instituto Carlos III, Madrid, Spain.

出版信息

J Allergy Clin Immunol Pract. 2019 Jan;7(1):191-198. doi: 10.1016/j.jaip.2018.07.023. Epub 2018 Aug 1.

DOI:10.1016/j.jaip.2018.07.023

PMID:30075342

Abstract

BACKGROUND

Two-component epoxy resin systems (ERSs) composed of epoxy resin and polyamine hardeners are extensively used in industrial and construction coating. Triglycidyl isocyanurate (TGIC) is another type of epoxy derivative, mostly encountered in polyester powder paints. Epoxy compounds are well-known skin sensitizers, but their respiratory-sensitizing potential is largely unknown.

OBJECTIVE

To report patients examined for occupational asthma (OA) from epoxy compounds.

METHODS

We retrospectively reviewed patient files of cases tested with a placebo-controlled specific inhalation challenge (SIC) according to their workplace exposure-either by mixing epoxy resin and the polyamine hardener of a 2-component paint or by dusting or heating TGIC-containing powder paint. The data were collected from the Finnish Institute of Occupational Health, Helsinki, Finland, and at Fundación Jiménez Díaz Hospital, Madrid, Spain, during 1997 to 2018. We also measured airborne polyamine and solvent vapors at the workplace and during SIC with ERSs.

RESULTS

Altogether 113 patients with work-related asthma symptoms underwent SIC with ERSs. Fifteen cases (13%) had positive SIC reactions confirming OA; in 12 cases reactions were late-type, in 1 case early, and in 2 cases combined. The median duration of exposure for patients with OA was 10 years; 2 of them (13%) had a diagnosis of allergic contact dermatitis from ERS compounds. In addition, 3 cases had a positive SIC reaction to TGIC. The airborne polyamine levels measured were low.

CONCLUSION

ERSs and TGIC can cause sensitizer-induced OA in some exposed workers. Respiratory exposure to ERSs is difficult to demonstrate using air measurements.

摘要

背景

由环氧树脂和聚酰胺固化剂组成的双组分环氧树脂系统（ERSs）广泛应用于工业和建筑涂料。三缩水甘油异氰尿酸酯（TGIC）是另一种类型的环氧树脂衍生物，主要用于聚酯粉末涂料。环氧树脂是众所周知的皮肤致敏剂，但它们的呼吸道致敏潜力在很大程度上尚未可知。

目的

报告因接触环氧树脂而接受职业性哮喘（OA）检查的患者。

方法

我们回顾性地审查了根据工作场所暴露情况接受安慰剂对照特异性吸入挑战（SIC）测试的患者病历，这些暴露情况包括混合环氧树脂和双组分涂料的聚酰胺固化剂、粉末涂料的粉尘或加热。这些数据来自芬兰职业健康研究所（位于芬兰赫尔辛基）和西班牙马德里 Jiménez Díaz 基金会医院，收集时间为 1997 年至 2018 年。我们还在工作场所和 SIC 期间使用 ERS 测量空气中的聚胺和溶剂蒸气。

结果

共有 113 名有职业相关哮喘症状的患者接受了 ERS 的 SIC 测试。15 例（13%）的 SIC 反应呈阳性，证实为 OA；其中 12 例为迟发型反应，1 例为早发型反应，2 例为混合型反应。OA 患者的中位暴露时间为 10 年；其中 2 例（13%）对 ERS 化合物有过敏性接触性皮炎的诊断。此外，3 例对 TGIC 的 SIC 反应呈阳性。测量的空气中聚胺水平较低。