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Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.

作者信息

Cruise J L, Cotecchia S, Michalopoulos G

出版信息

J Cell Physiol. 1986 Apr;127(1):39-44. doi: 10.1002/jcp.1041270106.

DOI:10.1002/jcp.1041270106
PMID:3007540
Abstract

Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an alpha 1-specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction in EGF receptor number, without a significant change in receptor affinity.

摘要

相似文献

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