德国慢性鼻-鼻窦炎患者的药物使用情况 - 一项基于患者的大型回顾性研究。

Medication use in patients with chronic rhinosinusitis in Germany - a large retrospective patient-based study.

机构信息

Department of Otorhinolaryngology and Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth-Hospital, Bochum, Germany.

Department of Otorhinolaryngology, Head and Neck Surgery, Solingen Municipal Hospital, Solingen, Germany.

出版信息

Rhinology. 2019 Apr 1;57(2):94-100. doi: 10.4193/Rhin18.055.

DOI:10.4193/Rhin18.055

PMID:30076702

Abstract

BACKGROUND

The aim of the present study was to provide an insight into medical treatment practices among patients with chronic rhinosinusitis (CRS) in Germany. An investigation of ICD codes and ATC classes of CRS patients in general and otolaryngology offices in Germany should reveal the prevalent treatment behaviors of German physicians.

METHODS

The present study used data from the Disease Analyzer database (IQVIA). The study sample included patients from 940 general (GP) and 106 otolaryngology (ENT) practices who were coded as having chronic sinusitis (ICD-10: J32) or nasal polyps (ICD-10: J33) in 2015 (index date). The primary outcome measures were the number of patients with these diagnoses per practice as well as the proportion of patients with prescriptions for topical corticosteroids, systemic corticosteroids, antibiotics, antihistamines, and local decongestants within 365 days after the first diagnosis.

RESULTS

This retrospective study included 26,768 patients with coding for chronic sinusitis (ICD-10: J32) and 516 patients for nasal polyps (ICD-10: J33) in 940 GP practices and 19,826 patients with coding for chronic sinusitis (ICD-10: J32) and 1,773 patients for nasal polyps (ICD-10: J33) in 106 ENT practices. In patients coded as having chronic sinusitis (ICD-10: J32), topical corticosteroids were prescribed at a low rate (GP: 12.3%, ENT: 34.3%). In patients coded as having nasal polyps (ICD-10: J33), topical corticosteroid usage was higher in GP practices (27.3%) and in ENT practices (71.2%).

CONCLUSIONS

Topical corticosteroid usage in CRS patients in GP practices in Germany is as low as in other Western countries. Increased usage of topical corticosteroids in CRS patients with polyposis should be encouraged in GP and ENT practices.

摘要

背景

本研究旨在深入了解德国慢性鼻-鼻窦炎（CRS）患者的治疗实践。对德国一般（GP）和耳鼻喉科（ENT）诊所的 CRS 患者的 ICD 代码和 ATC 分类进行调查，应能揭示德国医生的常见治疗行为。

方法

本研究使用 IQVIA 的疾病分析器（Disease Analyzer）数据库中的数据。研究样本包括 2015 年在 940 家普通（GP）和 106 家耳鼻喉科（ENT）诊所就诊的编码为慢性鼻窦炎（ICD-10：J32）或鼻息肉（ICD-10：J33）的患者。主要观察指标为每个诊所的这些诊断患者人数以及在首次诊断后 365 天内接受局部皮质类固醇、全身皮质类固醇、抗生素、抗组胺药和局部减充血剂治疗的患者比例。

结果

这项回顾性研究包括在 940 家 GP 诊所编码为慢性鼻窦炎（ICD-10：J32）的 26768 例患者和编码为鼻息肉（ICD-10：J33）的 516 例患者，以及在 106 家 ENT 诊所编码为慢性鼻窦炎（ICD-10：J32）的 19826 例患者和编码为鼻息肉（ICD-10：J33）的 1773 例患者。在编码为慢性鼻窦炎（ICD-10：J32）的患者中，局部皮质类固醇的使用率较低（GP：12.3%，ENT：34.3%）。在编码为鼻息肉（ICD-10：J33）的患者中，GP 诊所（27.3%）和 ENT 诊所（71.2%）中局部皮质类固醇的使用率更高。