Schryver Eric, Klein Gordon L, Herndon David N, Suman Oscar E, Branski Ludwik K, Sousse Linda E
Shriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA.
Shriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Orthopedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX 77555, USA.
Burns. 2018 Dec;44(8):1863-1869. doi: 10.1016/j.burns.2018.04.014. Epub 2018 Aug 1.
Severe burns in children can lead to growth delays, bone loss, and wasting of lean body mass and muscle with subsequent long-term effects such as osteoporosis. The following review examines 11 randomized, placebo-controlled, prospective clinical trials in pediatric burns between 1995 and 2017. These studies included approximately 250 burned children, and they were conducted to evaluate the impact of severe burn on markers of bone formation and bone metabolism. Some trials also analyzed current therapy regimens such as pamidronate and vitamin D. The clinical utility of these outlined biomarkers is uncertain with regard to acute burn care, as the current literature remains unclear. This review thus serves to address the impact of severe burn on markers of bone formation and bone metabolism in pediatric patients but will not focus on the clinical utility of the markers. The aim of this review is to summarize the findings of the trials to guide the future care of burned patients to maximize bone recovery.
儿童严重烧伤可导致生长发育迟缓、骨质流失以及瘦体重和肌肉消耗，继而产生如骨质疏松等长期影响。以下综述考察了1995年至2017年间针对小儿烧伤开展的11项随机、安慰剂对照的前瞻性临床试验。这些研究纳入了约250名烧伤儿童，旨在评估严重烧伤对骨形成和骨代谢标志物的影响。一些试验还分析了诸如帕米膦酸盐和维生素D等当前的治疗方案。就急性烧伤护理而言，这些概述的生物标志物的临床效用尚不确定，因为当前文献仍不明确。因此，本综述旨在探讨严重烧伤对小儿患者骨形成和骨代谢标志物的影响，但不会聚焦于这些标志物的临床效用。本综述的目的是总结试验结果，以指导烧伤患者的未来护理，使骨恢复最大化。
