Department of Biology, University of Ottawa, Ontario, K1N 6N5, Canada.
Department of Biology, University of Ottawa, Ontario, K1N 6N5, Canada.
Int J Hyg Environ Health. 2018 Aug;221(7):1023-1031. doi: 10.1016/j.ijheh.2018.07.001. Epub 2018 Jul 7.
The objective of the present work is to assess the factors associated with whole blood and urinary selenium (Se) concentrations in Canadians aged 6-79 years old, and to interpret the data in the context of exposure guidance values.
Whole blood Se concentrations data collected from 10740 participants as part of the Canadian Health Measures Survey (CHMS) Cycle 1 (2007-09) and Cycle 2 (2010-11) were analyzed for associations with the demographic and dietary characteristics of the Canadian population; whereas the urinary Se concentrations were only assessed for their association with the demographic variables. Whole blood and urinary Se concentrations were compared to biomonitoring equivalents established for exposure guidance values.
The geometric means of whole blood Se concentrations (μg/L) were 197.42 (95% CI: 194.79, 200.08) and 192.35 (95% CI: 189.68, 195.06) for males and females, respectively. The corresponding urinary Se concentrations (μg/L) were 56.91 (95% CI: 54.81, 59.10) and 44.10 (95% CI: 41.89, 46.43) respectively. Males, participants born in Asia, older individuals, and participants who frequently consumed nuts and vegetables had higher whole blood Se, whereas current smokers, residents of Quebec and Ontario, participants who frequently consumed meat, fruits or dairy products were associated with lower whole blood Se. Sociodemographic factors were also significantly associated with urinary Se although the direction of association sometimes differed from those observed with blood Se. More than 99.9% of the Canadian population covered by the survey had whole blood Se concentrations within the range from the lower (100 μg/L) and higher (400 μg/L) biomonitoring equivalents set for the protection from deficiency and selenosis, respectively.
The CHMS data provide a baseline for Se exposure among Canadians and indicated that the population is generally not at risk of deficiency or toxicity.
本研究旨在评估加拿大 6-79 岁人群全血和尿液硒（Se）浓度的相关因素，并结合暴露指导值对数据进行解释。
对 10740 名参与者在加拿大健康测量调查（CHMS）第 1 周期（2007-09 年）和第 2 周期（2010-11 年）中收集的全血 Se 浓度数据进行分析，以研究其与加拿大人群的人口统计学和饮食特征的相关性；而尿液 Se 浓度仅评估其与人口统计学变量的相关性。比较全血和尿液 Se 浓度与暴露指导值建立的生物监测等效物。
男性和女性全血 Se 浓度（μg/L）的几何均数分别为 197.42（95%置信区间：194.79，200.08）和 192.35（95%置信区间：189.68，195.06）。相应的尿液 Se 浓度（μg/L）分别为 56.91（95%置信区间：54.81，59.10）和 44.10（95%置信区间：41.89，46.43）。男性、出生于亚洲的参与者、年龄较大的参与者和经常食用坚果和蔬菜的参与者全血 Se 水平较高，而经常吸烟、居住在魁北克省和安大略省的参与者、经常食用肉类、水果或乳制品的参与者全血 Se 水平较低。人口统计学因素也与尿液 Se 显著相关，尽管其与血液 Se 的关联方向有时不同。在调查覆盖的加拿大人群中，超过 99.9%的人全血 Se 浓度处于分别为保护缺乏症和硒中毒而设定的较低（100μg/L）和较高（400μg/L）生物监测等效物范围内。
CHMS 数据提供了加拿大人群 Se 暴露的基线数据，并表明人群一般不存在缺乏症或中毒的风险。
