Kim HaEun, Park Yoon Jung
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.
Clin Nutr Res. 2018 Jul;7(3):153-160. doi: 10.7762/cnr.2018.7.3.153. Epub 2018 Jul 26.
Cancer metabolism is considered as one of major cancer hallmarks. It is important to understand cancer-specific metabolic changes and its impact on cancer biology to identify therapeutic potentials. Among cancer-specific metabolic changes, a role of serine metabolism has been discovered in various cancer types. Upregulation of serine synthesis pathway (SSP) supports cell proliferation and metastasis. The change of serine metabolism is, in part, mediated by epigenetic modifiers, such as Euchromatic histone-lysine N-methyltransferase 2 and Lysine Demethylase 4C. On the other hand, SSP also influences epigenetic landscape such as methylation status of nucleic acids and histone proteins via affecting S-adenosyl methionine production. In the review, we highlight recent evidences on interactions between SSP and epigenetic regulation in cancer. It may provide an insight on roles and regulation of SSP in cancer metabolism and the potential of serine metabolism for cancer therapy.
癌症代谢被认为是主要的癌症标志之一。了解癌症特异性代谢变化及其对癌症生物学的影响对于确定治疗潜力很重要。在癌症特异性代谢变化中，丝氨酸代谢在多种癌症类型中发挥了作用。丝氨酸合成途径（SSP）的上调支持细胞增殖和转移。丝氨酸代谢的变化部分由表观遗传修饰因子介导，如 euchromatic histone-lysine N-methyltransferase 2 和 Lysine Demethylase 4C。另一方面，SSP 还通过影响 S-腺苷甲硫氨酸的产生来影响表观遗传格局，如核酸和组蛋白的甲基化状态。在这篇综述中，我们重点介绍了关于 SSP 与癌症中表观遗传调控之间相互作用的最新证据。这可能为 SSP 在癌症代谢中的作用和调控以及丝氨酸代谢在癌症治疗中的潜力提供见解。
