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青少年饮酒与成年后果关系的同卵双生子对照研究。

A Co-Twin Control Study of the Relationship Between Adolescent Drinking and Adult Outcomes.

机构信息

College of Applied Behavioral Sciences, University of Indianapolis, Indianapolis, Indiana.

Department of Psychology, University of Minnesota, Minneapolis, Minnesota.

出版信息

J Stud Alcohol Drugs. 2018 Jul;79(4):635-643. doi: 10.15288/jsad.2018.79.635.

Abstract

OBJECTIVE

The effect of drinking during adolescence on adult functioning is a public health concern. A variety of mechanisms have been proposed where drinking in adolescence has an adverse impact on later outcomes; unfortunately, few studies have included methodologies that account for confounding influences that might link adolescent drinking with subsequent problems. To address this limitation, the current study used a co-twin control design, which uses members of twin pairs that differ from each other on their adolescent drinking.

METHOD

We used a prospective longitudinal sample drawn from the Minnesota Twin Family Study, consisting of 2,764 twins (1,434 female) assessed at regular follow-ups from age 17 to age 29. Adolescent drinking was defined by measures of early initiation of use and a measure of overall consumption at age 17. Adult outcomes included indicators of substance use, antisocial behavior, personality, socioeconomic status, and social functioning.

RESULTS

The co-twin control analyses suggested that many of the associations between adolescent drinking and later outcomes were largely influenced by genetic confounding. However, for the measure of adolescent alcohol consumption, results were consistent with a small causal impact of drinking on multiple domains of adult functioning. This pattern was less consistently observed for the measures of early initiation.

CONCLUSIONS

These results provide empirical justification for policies designed to alleviate long-term consequences associated with adolescent drinking by reducing the level of alcohol consumption in adolescence. In contrast, the evidence did not suggest that delaying drinking would have a broad impact on later-life adjustment.

摘要

目的

青少年期饮酒对成年功能的影响是一个公共卫生关注点。有多种机制被提出,即青少年饮酒对后期结果有不利影响;遗憾的是,很少有研究采用方法学来解释可能将青少年饮酒与随后的问题联系起来的混杂影响。为了解决这一局限性,本研究采用了同卵双生子对照设计,该设计利用了在青少年期饮酒方面存在差异的同卵双生子对成员。

方法

我们使用了来自明尼苏达州双胞胎家庭研究的前瞻性纵向样本,该样本包括在 17 岁至 29 岁期间定期随访的 2764 对双胞胎(1434 名女性)。青少年饮酒通过早期使用的起始衡量标准和 17 岁时的整体饮酒量衡量标准来定义。成人结局包括物质使用、反社会行为、个性、社会经济地位和社会功能的指标。

结果

同卵双生子对照分析表明,青少年饮酒与后期结果之间的许多关联在很大程度上受到遗传混杂的影响。然而,对于青少年饮酒量的衡量标准,结果与饮酒对成年功能多个领域的小因果影响一致。对于早期起始的衡量标准,这种模式的观察结果则不那么一致。

结论

这些结果为旨在通过减少青少年期饮酒量来减轻与青少年饮酒相关的长期后果的政策提供了经验依据。相比之下,这些证据并未表明延迟饮酒会对以后的生活调整产生广泛影响。

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