He Songliang, Zhu Guoshuai, Sun Zhencheng, Wang Jidong, Hui Ping, Zhao Penghe, Chen Wenwen, Jiang Xingyu
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center Shenzhen 518055 China
Central Laboratory, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen Nanshan People's Hospital and the 6th Affiliated Hospital of Shenzhen University Health Science Center Shenzhen 518052 China.
Nanoscale Adv. 2020 Jun 26;2(8):3550-3560. doi: 10.1039/d0na00342e. eCollection 2020 Aug 11.
The complicated synthesis and undesirable biocompatibility of nanomaterials hinder the synergistic photothermal/photodynamic therapy for bacterial infections. Herein, we develop a one-step preparation method of 2D AuPd alloy nanosheets as imaging-guided photonic nano-antibiotics. 2D AuPd alloy nanosheets with an extremely small thickness (∼1.5 nm) exhibit prominent photothermal effects ( = 76.6%), excellent ROS generation, strong photoacoustic signals and desirable biocompatibility. AuPd nanosheets can eliminate 100% of representative Gram-positive () and Gram-negative bacteria () when irradiated using an 808 nm laser at 1 W cm for 5 minutes. After being modified with a bacterial targeting peptide, under the guidance of photoacoustic imaging, AuPd nanosheets achieve promising synergistic photothermal/photodynamic therapeutic efficacy in treating infected mice. This work expands the biomedical application of 2D noble metal nanomaterials to the field of photonic nano-antibiotics.
纳米材料复杂的合成过程和不良的生物相容性阻碍了用于细菌感染的光热/光动力协同治疗。在此，我们开发了一种二维金钯合金纳米片的一步制备方法，作为成像引导的光子纳米抗生素。厚度极小（约1.5纳米）的二维金钯合金纳米片表现出显著的光热效应（η = 76.6%）、出色的活性氧生成能力、强烈的光声信号和良好的生物相容性。当使用808纳米激光以1瓦/平方厘米的功率照射5分钟时，金钯纳米片可消除100%的代表性革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）。在用细菌靶向肽修饰后，在光声成像的引导下，金钯纳米片在治疗金黄色葡萄球菌感染的小鼠方面实现了有前景的光热/光动力协同治疗效果。这项工作将二维贵金属纳米材料的生物医学应用扩展到了光子纳米抗生素领域。
