Lehmkuhl H D, Cutlip R C
Am J Vet Res. 1986 Apr;47(4):724-6.
Twelve 1-week-old colostrum-deprived lambs inoculated with the RTS-42 strain of Mastadenovirus ovi 5 were killed and necropsied (2 lambs/day) on postinoculation days (PID) 2, 4, 6, 8, 12, and 21. Four noninoculated lambs were killed and necropsied (2/day) on PID 6 and 12. Virus was isolated from nasal secretions and feces on PID 1 to PID 6, from tracheal fluids and lung tissue of lambs necropsied on PID 2, 4, and 6, and from lung tissue from 1 lamb necropsied on PID 8. Virus was not recovered from liver, kidney, or small intestine of inoculated lambs or samples from noninoculated lambs. Serum antibody was first detected on PID 6 in the inoculated lambs. Noninoculated lambs remained seronegative. None of the lambs in the study developed clinical signs of infection although lesions were produced in the respiratory tract.
给12只1周龄初乳剥夺羔羊接种禽腺病毒5型RTS - 42株，在接种后第2、4、6、8、12和21天（每天2只羔羊）将其处死并进行尸检。4只未接种的羔羊在接种后第6天和第12天（每天2只）被处死并进行尸检。在接种后第1天至第6天从鼻分泌物和粪便中分离到病毒，在接种后第2、4和6天处死的羔羊的气管液和肺组织中以及在接种后第8天处死的1只羔羊的肺组织中分离到病毒。在接种羔羊的肝脏、肾脏或小肠以及未接种羔羊的样本中未分离到病毒。接种羔羊在接种后第6天首次检测到血清抗体。未接种羔羊仍为血清阴性。尽管呼吸道出现了病变，但研究中的羔羊均未出现感染的临床症状。
