Cutlip R C, Lehmkuhl H D
Am J Vet Res. 1983 Dec;44(12):2395-402.
Young lambs, inoculated with ovine adenovirus isolate RTS-151, were killed sequentially (to postinoculation day 21), and their morphologic lesions were studied. Lesions were found only in the respiratory tract and were most severe in the terminal airways. Many cells of the respiratory epithelium had severe cytomegaly and karyomegaly with intranuclear inclusions. Desquamation of affected cells was accompanied by hyperplasia of airway and alveolar epithelium and by accumulation of necrotic cellular debris and neutrophils in terminal airways and alveoli. Virus replicated in the nucleus of enlarged epithelial cells in the airways, but not in alveolar epithelium. Intranuclear inclusions representing viral replication progressed from clumps of finely granular material without virions to a granular material with virions and finally to a dense inclusion with numerous virions.
给幼羊接种绵羊腺病毒分离株RTS - 151后，按顺序处死（直至接种后第21天），并对其形态学病变进行研究。病变仅见于呼吸道，且在终末气道最为严重。呼吸道上皮的许多细胞出现严重的细胞肿大和核肿大，并伴有核内包涵体。受影响细胞的脱落伴随着气道和肺泡上皮的增生，以及终末气道和肺泡中坏死细胞碎片和中性粒细胞的积聚。病毒在气道中增大的上皮细胞核内复制，但不在肺泡上皮中复制。代表病毒复制的核内包涵体从无病毒粒子的细颗粒物质团块发展为有病毒粒子的颗粒物质，最后发展为含有大量病毒粒子的致密包涵体。
