• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

持续的尖峰活动是工作记忆的基础。

Persistent Spiking Activity Underlies Working Memory.

机构信息

Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157,

Kokoro Research Center, Kyoto University, Yoshida Sakyo-ku, Kyoto, 606-8501, Japan.

出版信息

J Neurosci. 2018 Aug 8;38(32):7020-7028. doi: 10.1523/JNEUROSCI.2486-17.2018.

DOI:10.1523/JNEUROSCI.2486-17.2018
PMID:30089641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6083457/
Abstract

Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.Working Memory: Delay Activity, Yes! Persistent Activity? Maybe Not, by Mikael Lundqvist, Pawel Herman, and Earl K. Miller.

摘要

工作记忆任务延迟期前额叶皮层中持续的活动代表了记忆中保持的刺激信息,并决定了工作记忆的表现。其他工作记忆模型,无论是依赖于放电的节律性还是仅依赖于短期突触可塑性,都与神经生理学数据不一致。工作记忆:延迟活动,是的!持续活动?也许不是,作者:Mikael Lundqvist、Pawel Herman 和 Earl K. Miller。

相似文献

1
Persistent Spiking Activity Underlies Working Memory.持续的尖峰活动是工作记忆的基础。
J Neurosci. 2018 Aug 8;38(32):7020-7028. doi: 10.1523/JNEUROSCI.2486-17.2018.
2
Working Memory: Delay Activity, Yes! Persistent Activity? Maybe Not.工作记忆:延迟活动,没错!持续活动?可能并非如此。
J Neurosci. 2018 Aug 8;38(32):7013-7019. doi: 10.1523/JNEUROSCI.2485-17.2018.
3
Attention and working memory: a dynamical model of neuronal activity in the prefrontal cortex.注意力与工作记忆:前额叶皮层神经元活动的动力学模型
Eur J Neurosci. 2003 Oct;18(8):2374-90. doi: 10.1046/j.1460-9568.2003.02956.x.
4
Turning on and off with excitation: the role of spike-timing asynchrony and synchrony in sustained neural activity.由兴奋开启与关闭:峰电位时间异步性和同步性在持续神经活动中的作用。
J Comput Neurosci. 2001 Sep-Oct;11(2):121-34. doi: 10.1023/a:1012837415096.
5
A working memory model based on fast Hebbian learning.基于快速赫布学习的工作记忆模型。
Network. 2003 Nov;14(4):789-802.
6
Stable and Dynamic Coding for Working Memory in Primate Prefrontal Cortex.灵长类前额叶皮层工作记忆的稳定与动态编码
J Neurosci. 2017 Jul 5;37(27):6503-6516. doi: 10.1523/JNEUROSCI.3364-16.2017. Epub 2017 May 30.
7
A large-scale neurocomputational model of task-oriented behavior selection and working memory in prefrontal cortex.前额叶皮质中面向任务的行为选择和工作记忆的大规模神经计算模型。
J Cogn Neurosci. 2006 Feb;18(2):242-57. doi: 10.1162/089892906775783624.
8
Coding specificity in cortical microcircuits: a multiple-electrode analysis of primate prefrontal cortex.皮层微回路中的编码特异性:对灵长类前额叶皮层的多电极分析
J Neurosci. 2001 May 15;21(10):3646-55. doi: 10.1523/JNEUROSCI.21-10-03646.2001.
9
Short-term plasticity explains irregular persistent activity in working memory tasks.短期可塑性解释了工作记忆任务中不规则持续活动的原因。
J Neurosci. 2013 Jan 2;33(1):133-49. doi: 10.1523/JNEUROSCI.3455-12.2013.
10
Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex.多巴胺在前额叶皮质网络模型中对延迟期活动的介导性稳定作用
J Neurophysiol. 2000 Mar;83(3):1733-50. doi: 10.1152/jn.2000.83.3.1733.

引用本文的文献

1
Hippocampal stimulation reveals causal role of persistent neural activity in human working memory.海马体刺激揭示了持续性神经活动在人类工作记忆中的因果作用。
bioRxiv. 2025 Aug 21:2025.08.20.671301. doi: 10.1101/2025.08.20.671301.
2
Frontotemporal bursting supports human working memory.额颞叶爆发支持人类工作记忆。
bioRxiv. 2025 Jul 27:2025.07.26.666946. doi: 10.1101/2025.07.26.666946.
3
Unattended working memory items are coded by persistent activity in human medial temporal lobe neurons.无人看管的工作记忆项目由人类内侧颞叶神经元的持续活动编码。
Nat Hum Behav. 2025 Jul 9. doi: 10.1038/s41562-025-02235-0.
4
Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex.稀疏神经元亚群中补体C4增加诱导前额叶皮质全网络转录组改变。
bioRxiv. 2025 May 29:2025.05.29.656749. doi: 10.1101/2025.05.29.656749.
5
Balanced state of networks of winner-take-all units.赢者通吃单元网络的平衡状态
PLoS Comput Biol. 2025 Jun 11;21(6):e1013081. doi: 10.1371/journal.pcbi.1013081. eCollection 2025 Jun.
6
Unraveling the roles of spatial working memory sustained and selective neurons in prefrontal cortex.揭示前额叶皮层中空间工作记忆持续神经元和选择性神经元的作用。
Commun Biol. 2025 May 20;8(1):767. doi: 10.1038/s42003-025-08211-8.
7
Functional role of cell classes in monkey prefrontal cortex after learning a working memory task.学习工作记忆任务后猴前额叶皮层中细胞类别的功能作用。
Commun Biol. 2025 May 6;8(1):703. doi: 10.1038/s42003-025-08142-4.
8
Hippocampal sequences represent working memory and implicit timing.海马序列代表工作记忆和内隐计时。
bioRxiv. 2025 Mar 17:2025.03.17.643736. doi: 10.1101/2025.03.17.643736.
9
Mixed recurrent connectivity in primate prefrontal cortex.灵长类前额叶皮层中的混合循环连接
PLoS Comput Biol. 2025 Mar 11;21(3):e1012867. doi: 10.1371/journal.pcbi.1012867. eCollection 2025 Mar.
10
Naturalistic computational psychiatry: How to get there?自然主义计算精神病学:如何实现?
J Psychiatry Neurosci. 2025 Feb 7;50(1):E67-E72. doi: 10.1503/jpn.250009. Print 2025 Jan-Feb.

本文引用的文献

1
Persistent neuronal activity in human prefrontal cortex links perception and action.人类前额叶皮质中持续的神经元活动将感知与行动联系起来。
Nat Hum Behav. 2018 Jan;2(1):80-91. doi: 10.1038/s41562-017-0267-2. Epub 2017 Dec 18.
2
Different Levels of Category Abstraction by Different Dynamics in Different Prefrontal Areas.不同前额叶区域的不同动力学导致不同层次的类别抽象。
Neuron. 2018 Feb 7;97(3):716-726.e8. doi: 10.1016/j.neuron.2018.01.009. Epub 2018 Jan 27.
3
Gamma and beta bursts during working memory readout suggest roles in its volitional control.伽马和β爆发在工作记忆读出过程中,表明其在意志控制中的作用。
Nat Commun. 2018 Jan 26;9(1):394. doi: 10.1038/s41467-017-02791-8.
4
Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory.额皮质层的层状记录表明,工作记忆的维持和控制存在不同的层次。
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1117-1122. doi: 10.1073/pnas.1710323115. Epub 2018 Jan 16.
5
Low-Beta Oscillations Turn Up the Gain During Category Judgments.低频振荡提高类别判断时的增益。
Cereb Cortex. 2018 Jan 1;28(1):116-130. doi: 10.1093/cercor/bhw356.
6
Mixed selectivity morphs population codes in prefrontal cortex.混合选择性形态改变前额叶皮层的群体代码。
Nat Neurosci. 2017 Dec;20(12):1770-1779. doi: 10.1038/s41593-017-0003-2. Epub 2017 Oct 9.
7
Working Memory and Decision-Making in a Frontoparietal Circuit Model.前额顶叶回路模型中的工作记忆与决策制定
J Neurosci. 2017 Dec 13;37(50):12167-12186. doi: 10.1523/JNEUROSCI.0343-17.2017. Epub 2017 Nov 7.
8
Mechanisms of Persistent Activity in Cortical Circuits: Possible Neural Substrates for Working Memory.皮层回路持续活动的机制:工作记忆可能的神经基础。
Annu Rev Neurosci. 2017 Jul 25;40:603-627. doi: 10.1146/annurev-neuro-070815-014006.
9
Distinct timescales of population coding across cortex.整个皮层中群体编码的不同时间尺度。
Nature. 2017 Aug 3;548(7665):92-96. doi: 10.1038/nature23020. Epub 2017 Jul 19.
10
A Quadrantic Bias in Prefrontal Representation of Visual-Mnemonic Space.前额叶对视觉记忆空间的象限偏见。
Cereb Cortex. 2018 Jul 1;28(7):2405-2421. doi: 10.1093/cercor/bhx142.