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拉曼光谱在药物分析中的研究进展。

Research Progress of Raman Spectroscopy in Drug Analysis.

机构信息

Wanzhou Institute for Food and Drug Control, Chongqing, 404000, China.

Xian Libang Pharmaceutical Co., Ltd., Xian, 710075, China.

出版信息

AAPS PharmSciTech. 2018 Oct;19(7):2921-2928. doi: 10.1208/s12249-018-1135-8. Epub 2018 Aug 8.

Abstract

Raman spectroscopy is a spectroscopic analysis technique that enables rapid qualitative and quantitative detection based on inelastic collision and Raman scattering intensity. This review detailed the generation principle, instrument composition, influencing factors, and common classifications of Raman spectrum. Furthermore, it summarized and forecast the research progress of Raman spectroscopy in the field of drug analysis simultaneously over the past decade, including the identification of active pharmaceutical ingredients (APIs), qualitative and quantitative studies of pharmaceutical preparations, detection of illicit drugs, the identification of Chinese herbal medicines, and the combination with other technologies. The development of Raman spectroscopy in other fields is additionally summarized.

摘要

拉曼光谱是一种基于非弹性碰撞和拉曼散射强度的快速定性和定量分析技术。本综述详细介绍了拉曼光谱的产生原理、仪器组成、影响因素和常见分类。此外,总结和预测了过去十年中拉曼光谱在药物分析领域的研究进展,包括活性药物成分(APIs)的鉴定、药物制剂的定性和定量研究、非法药物的检测、中草药的鉴定以及与其他技术的结合。还总结了拉曼光谱在其他领域的发展。

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