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通过基因操纵和代谢工程改造的蓝细菌生产生物塑料化合物。

Production of Bioplastic Compounds by Genetically Manipulated and Metabolic Engineered Cyanobacteria.

作者信息

Katayama Noriaki, Iijima Hiroko, Osanai Takashi

机构信息

School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan.

出版信息

Adv Exp Med Biol. 2018;1080:155-169. doi: 10.1007/978-981-13-0854-3_7.

DOI:10.1007/978-981-13-0854-3_7
PMID:30091095
Abstract

Direct conversion of carbon dioxide to valuable compounds is a desirable way to reduce the environmental burden and switch from fossil to renewable fuels. Cyanobacteria are photosynthetic bacteria that perform oxygenic photosynthesis and are able to produce valuable compounds from carbon dioxide in the air. Synechocystis and Synechococcus species, model unicellular cyanobacteria, can produce succinate and lactate, which are commodity chemicals used to generate bioplastics. Several cyanobacteria are also able to produce polyhydroxybutyrate, a biodegradable polyester that accumulates under nitrogen or phosphorus starvation. Genetic manipulation succeeded in increasing the productivity of succinate, lactate, and polyhydroxybutyrate from cyanobacteria. We summarize the recent findings in this review.

摘要

将二氧化碳直接转化为有价值的化合物是减轻环境负担以及从化石燃料转向可再生燃料的理想途径。蓝细菌是进行产氧光合作用的光合细菌,能够利用空气中的二氧化碳生产有价值的化合物。单细胞蓝细菌模式生物集胞藻属和聚球藻属能够产生琥珀酸和乳酸,它们是用于生产生物塑料的商品化学品。几种蓝细菌还能够产生聚羟基丁酸酯,这是一种在氮或磷饥饿条件下积累的可生物降解聚酯。基因操作成功提高了蓝细菌生产琥珀酸、乳酸和聚羟基丁酸酯的产量。我们在本综述中总结了最近的研究发现。

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