Aoyama A, Saga S, Nagayoshi S, Hoshino M, Tomita T, Kondo K
Jpn J Cancer Res. 1986 Mar;77(3):244-9.
Large amounts of murine mammary tumor virus (MMTV) were expressed in milk from a low mammary tumor mouse strain called II-TES, established by crossbreeding DBA/2 mouse strain with two strains of Japanese pet mouse origin. The reciprocal hybrids of the II-TES strain and OZ-F strain, another low mammary tumor strain of Japanese pet mouse origin, developed early-appearing mammary tumors at a high rate, and large quantities of MMTV were expressed in the milk. These findings suggest that different regulatory genes control MMTV expression and mammary tumorigenesis.
通过将DBA/2小鼠品系与两种源自日本宠物小鼠的品系杂交建立的名为II-TES的低乳腺肿瘤小鼠品系的乳汁中表达了大量的鼠乳腺肿瘤病毒（MMTV）。II-TES品系与另一种源自日本宠物小鼠的低乳腺肿瘤品系OZ-F品系的正反交杂种以高比率发生早期出现的乳腺肿瘤，并且乳汁中表达了大量的MMTV。这些发现表明不同的调控基因控制MMTV表达和乳腺肿瘤发生。
