Institute for Experimental Pharmacology, Friedrich Alexander University Erlangen Nuremberg, Fahrstraße 17, 91054, Erlangen, Germany.
Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium.
Mol Imaging Biol. 2018 Oct;20(5):742-749. doi: 10.1007/s11307-018-1259-y.
Brain atlases play a key role in modern neuroimaging analysis of brain structure and function. We review available atlas databases for humans and animals and illustrate common state-of-the-art workflows in neuroimaging research based on image registration. Advances in noninvasive imaging methods, 3D ex vivo microscopy, and image processing are summarized which will eventually close the current resolution gap between brain atlases based on conventional 2D histology and those based on 3D in vivo imaging.
脑图谱在大脑结构和功能的现代神经影像学分析中起着关键作用。我们回顾了现有的人脑和动物脑图谱数据库,并根据图像配准展示了神经影像学研究中的常见最新工作流程。总结了非侵入性成像方法、3D 离体显微镜和图像处理方面的进展,这些进展最终将缩小基于传统 2D 组织学的脑图谱与基于 3D 体内成像的脑图谱之间的现有分辨率差距。