HIV Surveillance and Behavioural Monitoring Unit, National Center of Epidemiology, Carlos III Institute of Health, Madrid, Spain.
AIDS. 2018 Nov 13;32(17):2573-2581. doi: 10.1097/QAD.0000000000001989.
We aim to estimate the number of people living with HIV and the undiagnosed fraction in Spain, where coverage of the HIV surveillance system has only recently become complete.
The reconstruction of all HIV diagnoses and infections was obtained by combining HIV and AIDS surveillance data. The imputation of the diagnoses and back-calculation of the infection incidence are integrated in a Bayesian framework to take into account the uncertainty associated with unavailable data.
An estimated 141 000 [95% credible interval (CI) 128 000-155 000] persons were living with HIV by the end of 2013, in Spain and 18% (95% CI 14.3-22.1%) were unaware of it. A similar fraction of undiagnosed infections was obtained in men who have sex with men and heterosexuals (18.8 and 20.1%, respectively), but for injection drug users, this fraction was 3.5%.
This study provides the first estimates of the number of people living with HIV and the undiagnosed fraction in Spain, using routine surveillance data. The proposed method could be useful for countries where the geographical coverage of the HIV surveillance system is partial or was completed only recently.
我们旨在估计西班牙的艾滋病毒感染者人数和未确诊人群的比例,因为该国的艾滋病毒监测系统的覆盖范围最近才变得全面。
通过结合艾滋病毒和艾滋病监测数据,我们获得了所有艾滋病毒诊断和感染的重建。通过在贝叶斯框架中纳入诊断的推断和感染发病率的回溯计算,考虑到与不可用数据相关的不确定性。
到 2013 年底,西班牙估计有 141000 人(95%可信区间为 128000-155000)携带艾滋病毒,其中 18%(95%可信区间为 14.3-22.1%)不知道自己携带病毒。在男男性行为者和异性恋者中,也获得了类似比例的未确诊感染(分别为 18.8%和 20.1%),但对于注射毒品使用者,这一比例为 3.5%。
本研究使用常规监测数据,首次提供了西班牙艾滋病毒感染者人数和未确诊人群比例的估计值。该方法对于那些艾滋病毒监测系统的地理覆盖范围部分或最近才完成的国家可能有用。