Division of Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
Sci Rep. 2018 Aug 10;8(1):11976. doi: 10.1038/s41598-018-30265-4.
Alzheimer's disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer's disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet. In addition, we show that these memory deficits are rapidly reversed by switching mice from a high-fat diet back to a low-fat diet. These findings have important implications for the contribution of nutrition to the development of cognitive decline and Alzheimer's disease.
阿尔茨海默病是导致发病和死亡的主要原因，目前尚无治愈方法，治疗手段也十分有限。肥胖和 2 型糖尿病与认知能力下降和阿尔茨海默病的提前发生呈正相关，这将饮食与这些疾病联系起来。在这里，我们证明在高脂肪饮食仅一天后，小鼠的情景记忆，以及空间和上下文联想记忆就会受到损害。然而，物体记忆仍然完好无损。这不仅显示出比之前报道的更快的效果，而且还表明更复杂的记忆更容易受到高脂肪饮食的影响。此外，我们还表明，通过将小鼠从高脂肪饮食切换回低脂肪饮食，可以迅速逆转这些记忆缺陷。这些发现对营养在认知能力下降和阿尔茨海默病发展中的作用具有重要意义。
