Zarezadeh Meysam, Saedisomeolia Ahmad, Khorshidi Masoud, Kord Varkane Hamed, Makhdoomi Arzati Motahareh, Abdollahi Mina, Yekaninejad Mir Saeed, Hashemi Rezvan, Effatpanah Mohammad, Mohammadzadeh Honarvar Niyaz
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
J Complement Integr Med. 2018 Aug 11;16(2):/j/jcim.2019.16.issue-2/jcim-2018-0019/jcim-2018-0019.xml. doi: 10.1515/jcim-2018-0019.
Aims Patients with type 2 diabetes mellitus (T2DM) are prone to cardiovascular disease (CVD) due to inflammation process and oxidative stress. ADMA (Asymmetric dimethylarginine) and ICAM-1 (inter-cellular adhesion molecule-1) play an important role in CVD pathogenesis. Ginger as an anti-oxidant and anti-inflammation can effect on these biomarkers. The aim of present study was to characterize the effect of ginger supplementation on ADMA and ICAM-1 serum levels in patients with T2DM. Methods The present study is a randomized double-blind clinical trial which is conducted among 45 diabetic patients (nginger=23, nplacebo=22). The participants were randomly divided into two intervention and placebo groups which were received 2 g ginger powder and 2 g wheat flour for 10 weeks, respectively. ADMA and ICAM-1 concentration were measured by ELISA method. Results Ginger supplementation decreased ADMA serum levels significantly (P=0.002) and sICAM-1 serum levels marginally (P=0.097) in supplementation group after intervention. No significant difference was observed between placebo and supplementation groups. Conclusions Present study was conducted among patients with type 2 diabetes mellitus to investigate the effect of ginger supplementation on ADMA and sICAM-1 levels. There was a significant decrement in ADMA serum concentration and slight reduction in sICAM-1 levels in intervention group. The amount of reduction in both biomarkers was not statistically significant in between-groups comparison.
目的 2型糖尿病（T2DM）患者由于炎症过程和氧化应激，易患心血管疾病（CVD）。不对称二甲基精氨酸（ADMA）和细胞间黏附分子-1（ICAM-1）在CVD发病机制中起重要作用。生姜作为一种抗氧化剂和抗炎剂，可对这些生物标志物产生影响。本研究的目的是确定补充生姜对T2DM患者血清ADMA和ICAM-1水平的影响。方法 本研究是一项随机双盲临床试验，在45例糖尿病患者中进行（生姜组=23例，安慰剂组=22例）。参与者被随机分为两个干预组和安慰剂组，分别接受2克姜粉和2克小麦粉，持续10周。采用酶联免疫吸附测定（ELISA）法测量ADMA和ICAM-1浓度。结果 干预后，补充生姜组的ADMA血清水平显著降低（P=0.002），可溶性ICAM-1（sICAM-1）血清水平略有降低（P=0.097）。安慰剂组和补充生姜组之间未观察到显著差异。结论 本研究在2型糖尿病患者中进行，以研究补充生姜对ADMA和sICAM-1水平的影响。干预组的ADMA血清浓度显著降低，sICAM-1水平略有降低。两组之间这两种生物标志物的降低量在统计学上无显著差异。
