Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Complement Ther Med. 2019 Feb;42:7-11. doi: 10.1016/j.ctim.2018.10.019. Epub 2018 Oct 26.
The complications of diabetes are extensive which can be caused by excessive oxidative stress, inflammation and impaired insulin system. Plant-sourced bioactive compounds can reduce inflammation and oxidative stress. The aim of present study was to determine the effect of ginger supplementation on diabetic complications.
The present study is a randomized double blind clinical trial which is conducted with 48 diabetic patients. The participants were randomly divided into two intervention and placebo groups which were received 2 g ginger powder and 2 g wheat flour respectively for 10 weeks. Nuclear factor kappa B (NF-κB) concentration and anthropometric measurements were evaluated at the baseline and at the end of study.
The effect of ginger supplementation on hip circumference was marginal and there was no significant effect on BMI and waist circumference. Mean NF-κB p65 concentrations were reduced in ginger supplementation group, however, the amount was not statistically significant.
Ginger supplementation had significant effects on anthropometric evaluations. Ginger supplementation decreased mean NF-κB concentration in comparison with placebo, however the significance level was marginal. In order to achieve reliable information, more researches should be complemented with uptake of other diagnostic tools.
糖尿病的并发症广泛，可能是由过度的氧化应激、炎症和胰岛素系统受损引起的。植物源生物活性化合物可以减轻炎症和氧化应激。本研究的目的是确定姜黄补充剂对糖尿病并发症的影响。
本研究是一项随机双盲临床试验，共纳入 48 例糖尿病患者。参与者被随机分为两组，干预组和安慰剂组，分别接受 2g 姜黄粉和 2g 小麦粉，持续 10 周。在基线和研究结束时评估核因子 kappa B（NF-κB）浓度和人体测量学指标。
姜黄补充对臀围的影响是边缘的，对 BMI 和腰围没有显著影响。姜黄补充组 NF-κB p65 浓度降低，但无统计学意义。
姜黄补充对人体测量学评估有显著影响。与安慰剂相比，姜黄补充降低了平均 NF-κB 浓度，但显著性水平较低。为了获得可靠的信息，应补充其他诊断工具进行研究。
