Faculty of Health and Sports, University of Stirling, Stirling, United Kingdom.
Front Public Health. 2021 Jan 25;8:600427. doi: 10.3389/fpubh.2020.600427. eCollection 2020.
Diabetes is a long-term condition that can be treated and controlled but do not yet have a cure; it could be induced by inflammation and the goal of managing it is to prevent additional co-morbidities and reduce glycemic fluctuations. There is a need to examine inflammatory activities in diabetes-related angiopathies and explore interventions that could reduce the risk for future outcome or ameliorate its effects to provide insights for improved care and management strategies. The study was conducted in Embase (1946-2020), Ovid Medline (1950-2020), and PubMed databases (1960-2020) using the PICO framework. Primary studies (randomized controlled trials) on type 2 diabetes mellitus and inflammatory activities in diabetes-related angiopathies were included. Terms for the review were retrieved from the Cochrane library and from PROSPERO using its MeSH thesaurus qualifiers. Nine articles out of 454 total hits met the eligibility criteria. The quality assessment for the selected study was done using the Center for Evidence-Based Medicine Critical Appraisal Sheet. Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome. Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events. Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant ( < 0.05) reduction in inflammatory activities. Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
糖尿病是一种可以治疗和控制但尚未治愈的慢性疾病；它可能由炎症引起，其治疗目标是预防额外的合并症并减少血糖波动。需要检查糖尿病相关血管病变中的炎症活动，并探索可能降低未来风险或改善其效果的干预措施，为改善护理和管理策略提供依据。该研究在 Embase（1946-2020 年）、Ovid Medline（1950-2020 年）和 PubMed 数据库（1960-2020 年）中使用 PICO 框架进行。纳入了关于 2 型糖尿病和糖尿病相关血管病变中炎症活动的原发性研究（随机对照试验）。审查的术语是从 Cochrane 图书馆和 PROSPERO 使用其 MeSH 主题词限定词检索到的。在 454 篇总文献中，有 9 篇符合入选标准。使用循证医学中心批判性评估表对选定研究进行了质量评估。数据分析显示，在糖尿病相关血管病变中，升高的 CRP、TNF-α 和 IL-6 是最常见的炎症标志物，而升高的 IL-10 和可溶性 RAGE 是更好结果的标志物。使用药物，如柳氮磺胺吡啶、吡格列酮、辛伐他汀和非诺贝特，但不使用格列美脲或苯磷汀，报告炎症事件显著减少。有规律的运动和摄入具有抗炎特性的膳食补充剂，如姜、橙皮苷，以及含有益生元纤维（如覆盆子）的膳食补充剂，显示炎症活动持续显著（<0.05）降低。炎症活动与糖尿病相关血管病变有关；有规律的运动、摄入健康的膳食补充剂和具有抗炎特性的药物可以通过抑制炎症活动和提高抗炎事件，为糖尿病患者提供更好的保护风险结果。
