台湾人群中GRM7单核苷酸多态性与年龄相关性听力损失的关联
The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population.
作者信息
Chang Ning-Chia, Dai Chia-Yen, Lin Wen-Yi, Yang Hua-Ling, Wang Hsun-Mo, Chien Chen-Yu, Hsieh Meng-Hsuan, Ho Kuen-Yao
机构信息
Department of Otorhinolaryngology, Kaohsiung Medical University School of Medicine, Kaohsiung, Taiwan.
Department of Internal Medicine, Kaohsiung Medical University School of Medicine, Kaohsiung, Taiwan; Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
J Int Adv Otol. 2018 Aug;14(2):170-175. doi: 10.5152/iao.2018.5109.
OBJECTIVES
Age-related hearing impairment (ARHI) is a major disability among the elderly. This study aimed to analyze the association of single nucleotide polymorphisms (SNPs) of metabotropic glutamate receptor 7 (GRM7) gene with ARHI in an elderly population in Taiwan.
MATERIALS AND METHODS
This was a community-based study performed in a metropolitan hospital. Participants ≥65 years of age were recruited. Participants with a pure tone average (PTA) of speech frequencies in the better ear of >35 decibel hearing level (dBHL) were classified into the case group, whereas those with PTA ≤25 dBHL were classified into the control group. The association of SNPs rs11928865, rs1353828, rs9814809, and rs9880404 with ARHI was analyzed.
RESULTS
In 106 cases and 190 controls, alleles of all SNPs were found not to be associated with ARHI. The genotype of rs9880404 was found to be associated with ARHI in a dominant pattern, but the genotypes of rs11928865, rs1353828, and rs9814809 were found not to be associated with ARHI.
CONCLUSION
GRM7 SNPs are associated with susceptibility to ARHI, but the significance of this finding in a Taiwanese population differed from that observed in European studies. Further studies may help to determine Taiwanese (Asian)-specific SNPs associated with ARHI.
目的
年龄相关性听力减退（ARHI）是老年人中的一种主要残疾。本研究旨在分析台湾老年人群中代谢型谷氨酸受体7（GRM7）基因单核苷酸多态性（SNP）与ARHI的关联。
材料与方法
这是一项在一家都市医院进行的基于社区的研究。招募年龄≥65岁的参与者。较好耳言语频率纯音平均听阈（PTA）＞35分贝听力级（dBHL）的参与者被归入病例组，而PTA≤25 dBHL的参与者被归入对照组。分析SNP rs11928865、rs1353828、rs9814809和rs9880404与ARHI的关联。
结果
在106例病例和190例对照中，发现所有SNP的等位基因均与ARHI无关。发现rs9880404的基因型以显性模式与ARHI相关，但rs11928865、rs1353828和rs9814809的基因型与ARHI无关。
结论
GRM7 SNP与ARHI易感性相关，但这一发现对台湾人群的意义与欧洲研究中观察到的不同。进一步的研究可能有助于确定与ARHI相关的台湾（亚洲）特异性SNP。
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