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Oncotarget. 2017 Apr 7;8(31):50673-50679. doi: 10.18632/oncotarget.16929. eCollection 2017 Aug 1.
3
IL1R1 gene polymorphisms are associated with knee osteoarthritis risk in the Chinese Han population.白细胞介素1受体1（IL1R1）基因多态性与中国汉族人群膝骨关节炎风险相关。
Oncotarget. 2017 Jan 17;8(3):4228-4233. doi: 10.18632/oncotarget.13935.
4
Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease.炎症相关基因中六个CpG单核苷酸多态性与冠心病的关联
Hum Genomics. 2016 Jul 25;10 Suppl 2(Suppl 2):21. doi: 10.1186/s40246-016-0067-1.
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Int J Audiol. 2016 Sep;55(9):491-8. doi: 10.1080/14992027.2016.1182651. Epub 2016 May 24.
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Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells.胎儿胸腺移植可使年龄相关性听力损失得以恢复，并使表达白细胞介素-1受体2型的CD4阳性T细胞和调节性T细胞扩增。
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Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors.白细胞介素-1Ⅰ型和Ⅱ型受体基因多态性与膜结合受体表达水平之间的关系。
Cell Mol Immunol. 2015 Mar;12(2):222-30. doi: 10.1038/cmi.2014.43. Epub 2014 Jun 30.

白细胞介素-1 受体 1 型和 2 型基因多态性与台湾人群年龄相关性听力损失的关联：病例对照研究。

The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study.

机构信息

Department of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Department of Otorhinolaryngology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

出版信息

J Otolaryngol Head Neck Surg. 2020 Apr 6;49(1):16. doi: 10.1186/s40463-020-00410-z.

DOI:10.1186/s40463-020-00410-z
PMID:32252823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7137511/
Abstract

BACKGROUND

Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan.

METHOD

Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants.

RESULTS

The G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments.

CONCLUSION

These findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population.

摘要

背景

年龄相关性听力损失（ARHI）是老年人群中的主要残疾之一。慢性炎症是 ARHI 发展的重要因素。白细胞介素-1（IL-1）在炎症中起关键作用，可能与 ARHI 有关。本研究旨在分析白细胞介素 1 受体基因的单核苷酸多态性（SNP）与台湾老年人群 ARHI 的关系。

方法

招募年龄≥65 岁的参与者进行听力测试和基因分析。双侧高音听力平均（PTA）用于 ARHI 评估。分析白细胞介素 1 受体 1 型基因（IL1R1）（rs3917225 和 rs2234650）和 2 型基因（IL1R2）（rs4141134 和 rs2071008）的 SNP 与 ARHI 的关系，在 182 名 ARHI 易感（病例）和 176 名 ARHI 抗性（对照）参与者中进行分析。

结果

IL1R1 rs3917225 的 G 等位基因在调整性别、年龄和噪声暴露后，与 ARHI 的风险降低相关。所有遗传模型中 IL1R1 rs3917225 的 GG 基因型和隐性模型中 IL1R2 rs2071008 的 TT 基因型也在调整后显示出 ARHI 的风险降低。

结论

这些发现表明，IL1R1 和 IL1R2 多态性可能导致老年人群 ARHI 的风险降低。