植物固醇和植物甾烷醇研究的进展与展望。
Progress and perspectives in plant sterol and plant stanol research.
机构信息
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
出版信息
Nutr Rev. 2018 Oct 1;76(10):725-746. doi: 10.1093/nutrit/nuy032.
Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.
目前的证据表明，添加植物甾醇或植物固醇的食物可以降低血清中低密度脂蛋白胆固醇的水平。本综述总结了最近的发现和 31 位该领域专家在加拿大温尼伯举行的科学会议上的讨论，该会议涉及植物甾醇和植物固醇对健康的影响。与会者讨论的问题包括但不限于植物甾醇和植物固醇除了降低胆固醇之外的健康益处、植物甾醇和植物固醇作为饮食和药物辅助的作用，以及在生物样本中测量植物甾醇和植物固醇所涉及的挑战。还讨论了个体对植物甾醇和植物固醇反应的个体差异，以及降脂治疗的个体化。最后，还回顾了甾醇血症的临床方面和治疗。虽然植物甾醇和植物固醇仍然提供了一种有效的、方便的饮食控制胆固醇的方法，但仍缺乏长期临床试验来调查心血管疾病的终点。
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