Luo Wei, He Yong, Ding Fei, Nie Xin, Li Xiao-Ling, Song Hao-Lan, Li Gui-Xing
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
J Clin Lab Anal. 2019 Jan;33(1):e22650. doi: 10.1002/jcla.22650. Epub 2018 Aug 12.
The main risk factors for atherosclerosis patients are not fully explicated. The aim of this study was to analyze the levels of blood lipid and glycosylated lipoprotein in patients with coronary artery atherosclerosis and healthy individuals and to study the relationship between the glycosylated lipoprotein and atherosclerosis.
The study involved 200 patients diagnosed with myocardial infarction caused by coronary atherosclerosis as case group and 230 healthy individuals as control group. We analyzed and contrasted the levels of blood lipid and glycosylated lipoprotein between the different groups. In addition, we investigated the correlation between glycosylated low-density lipoprotein (G-LDL) and glucose levels.
There is no statistical difference between the level of TG in case group and control group. The level of CHOL, HDL-C, and LDL-C in case group is significantly lower than that in control group (3.90 [3.23, 4.42] vs 5.16 [4.86, 5.77] [mmol/L]; 1.09 [0.83, 1.38] vs 1.46 [1.15, 1.80] [mmol/L]; 2.22 [1.68, 2.81] vs 2.95 [2.60, 3.27] [mmol/L]) (P < 0.05). The level of GLU, HbA1c, G-HDL, and G-LDL in case group is significantly higher than that in control group (7.10 [5.68, 9.27] vs 4.84 [4.68, 5.07] [mmol/L]; 6.8 [6.3, 7.4] vs 5.9 [5.6, 6.1] [%]; 30.08 [25.04, 40.17] vs 22.95 [18.14, 27.06] [ng/mL], 6.26 [4.95, 7.50] vs 3.61 [2.66, 5.15] [ng/mL]) (p < 0.05). The level of G-LDL in patients with coronary atherosclerosis was relevant with the level of GLU and HbA1c (r = 0.625, 0.706, P < 0.05), and there was no relevance with LDL-C (r = 0.331, P > 0.05).
Hyperlipidemia is not an important cause of coronary atherosclerosis. High glucose levels and glycosylated lipoprotein are of high importance in the development and progression of coronary atherosclerosis.
动脉粥样硬化患者的主要危险因素尚未完全阐明。本研究旨在分析冠状动脉粥样硬化患者和健康个体的血脂及糖基化脂蛋白水平，并研究糖基化脂蛋白与动脉粥样硬化之间的关系。
本研究纳入200例诊断为冠状动脉粥样硬化所致心肌梗死的患者作为病例组，230例健康个体作为对照组。我们分析并对比了不同组之间的血脂及糖基化脂蛋白水平。此外，我们还研究了糖基化低密度脂蛋白（G-LDL）与血糖水平之间的相关性。
病例组和对照组的甘油三酯水平无统计学差异。病例组的胆固醇、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平显著低于对照组（3.90[3.23,4.42]对5.16[4.86,5.77][mmol/L]；1.09[0.83,1.38]对1.46[1.15,1.80][mmol/L]；2.22[1.68,2.81]对2.95[2.60,3.27][mmol/L]）（P<0.05）。病例组的血糖、糖化血红蛋白（HbA1c）、糖基化高密度脂蛋白（G-HDL）和糖基化低密度脂蛋白（G-LDL）水平显著高于对照组（7.10[5.68,9.27]对4.84[4.68,5.07][mmol/L]；6.8[6.3,7.4]对5.9[5.6,6.1][%]；30.08[25.04,40.17]对22.95[18.14,27.06][ng/mL]，6.26[4.95,7.50]对3.61[2.66,5.15][ng/mL]）（P<0.05）。冠状动脉粥样硬化患者的G-LDL水平与血糖和HbA1c水平相关（r=0.625，0.706，P<0.05），与LDL-C无关（r=0.331，P>0.05）。
高脂血症不是冠状动脉粥样硬化的重要原因。高血糖水平和糖基化脂蛋白在冠状动脉粥样硬化的发生和发展中具有重要意义。
