School of Engineering and Materials Science, Institute of Bioengineering, Queen Mary University of London, Mile End Road, E1 4NS, UK.
Macromol Biosci. 2019 Jan;19(1):e1800221. doi: 10.1002/mabi.201800221. Epub 2018 Aug 12.
Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.
肽和聚合物是水凝胶制备中的“精英”构建块，典型的方法是将特定的肽序列（细胞黏附和/或酶切）偶联到聚合物链上，旨在获得可控的细胞响应（黏附、迁移、分化）。然而，将聚合物和肽用作构建超分子水凝胶的结构成分的应用还不太成熟。本文综述了用于自组装成混合水凝胶的肽/聚合物系统的设计，包括肽-聚合物缀合物或分别组合这两种成分。然后，从潜在的生物医学应用的角度讨论了水凝胶的性质（硬度、网状结构、响应性和生物相容性）。
