Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, El-Geish Street, Tanta 31527, Egypt.
Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Mar Drugs. 2023 Feb 4;21(2):112. doi: 10.3390/md21020112.
Fucoidan is a heterogeneous group of polysaccharides isolated from marine organisms, including brown algae and marine invertebrates. The physicochemical characteristics and potential bioactivities of fucoidan have attracted substantial interest in pharmaceutical industries in the past few decades. These polysaccharides are characterized by possessing sulfate ester groups that impart negatively charged surfaces, low/high molecular weight, and water solubility. In addition, various promising bioactivities have been reported, such as antitumor, immunomodulatory, and antiviral effects. Hence, the formulation of fucoidan has been investigated in the past few years in diverse pharmaceutical dosage forms to be able to reach their site of action effectively. Moreover, they can act as carriers for various drugs in value-added drug delivery systems. The current work highlights the attractive biopharmaceutical properties of fucoidan being formulated in oral, inhalable, topical, injectable, and other advanced formulations treating life-quality-affecting diseases. Therefore, the present work points out the current status of fucoidan pharmaceutical formulations for future research transferring their application from in vitro and in vivo studies to clinical application and market availability.
岩藻聚糖是从海洋生物中分离得到的一组不均一多糖，包括褐藻和海洋无脊椎动物。在过去几十年中，岩藻聚糖的物理化学特性和潜在的生物活性引起了制药行业的极大兴趣。这些多糖的特点是具有赋予负电荷表面的硫酸酯基团、低/高分子量和水溶性。此外，还报道了各种有前途的生物活性，如抗肿瘤、免疫调节和抗病毒作用。因此，过去几年中已经研究了岩藻聚糖在各种药物剂型中的配方，以便能够有效地到达其作用部位。此外，它们可以作为各种药物在增值药物传递系统中的载体。目前的工作强调了岩藻聚糖在口服、吸入、局部、注射和其他先进制剂中具有吸引力的生物制药特性，这些制剂可用于治疗影响生活质量的疾病。因此，目前的工作指出了岩藻聚糖药物制剂的现状，以促进其从体外和体内研究向临床应用和市场应用的转化。
