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免疫功能正常患者的肺尖端赛多孢菌感染伴肺微小结节

Pulmonary Scedosporium apiospermum Infection with Pulmonary Tumorlet in an Immunocompetent Patient.

作者信息

Motokawa Nana, Miyazaki Taiga, Hara Atsuko, Fukuda Yuichi, Morino Shigeyuki, Nakamura Hiroaki, Iwasaki Keisuke, Soda Hiroshi, Izumikawa Koichi, Yanagihara Katsunori, Ohno Hideaki, Miyazaki Yoshitsugu, Kohno Shigeru, Mukae Hiroshi

机构信息

Division of Respiratory Medicine, Sasebo City General Hospital, Japan.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.

出版信息

Intern Med. 2018 Dec 1;57(23):3485-3490. doi: 10.2169/internalmedicine.1239-18. Epub 2018 Aug 10.

Abstract

Scedosporium apiospermum is an opportunistic fungus that can cause various types of infections, including localized infections and life-threatening disseminated infections, particularly in immunocompromised patients. Treatment is especially challenging due to its multidrug resistance. We herein report the case of a 73-year-old woman who was non-immunocompromised but developed S. apiospermum lung infection and a pulmonary tumorlet. To our knowledge, this is the first report of the coexistence of pulmonary S. apiospermum infection and tumorlet. The lung lesion was successfully treated by surgical excision without any antifungal agents, and no recurrence of the tumorlet or S. apiospermum infection has occurred.

摘要

伪阿利什霉是一种机会致病性真菌,可引起各种类型的感染,包括局部感染和危及生命的播散性感染,尤其是在免疫功能低下的患者中。由于其多重耐药性,治疗极具挑战性。我们在此报告一例73岁女性病例,该患者无免疫功能低下,但发生了伪阿利什霉肺部感染和肺微小瘤。据我们所知,这是首例肺部伪阿利什霉感染与肺微小瘤并存的报告。肺部病变通过手术切除成功治愈,未使用任何抗真菌药物,且肺微小瘤或伪阿利什霉感染均未复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4519/6306550/9f5e97812be4/1349-7235-57-3485-g001.jpg

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