Bingham S A
Nutr Health. 1985;4(1):17-23. doi: 10.1177/026010618500400103.
The hypothesis that lack of dietary fibre in the diet is responsible for a variety of large bowel problems, including cancer, has stimulated much discussion and research over the past 15 years. However, the epidemiological examination of this hypothesis has been hampered by the absence of data on the fibre content of most of the world's foods. In Scandinavia and Britain where the consumption of the major chemical fraction of dietary fibre, the non-starch polysaccharides, has been measured using accurate methods, significant negative associations have been shown with colon cancer occurrence. These studies suggest that non-starch polysaccharides may be protective in populations at otherwise high risk of colon cancer from an excess of meat and fat. However, methodological problems in the assessment of non-starch polysaccharide consumption in individuals preclude the use of case control studies in verifying these associations within a single homogeneous population.
饮食中缺乏膳食纤维会导致包括癌症在内的各种大肠问题，这一假说在过去15年里引发了诸多讨论和研究。然而，由于缺乏世界上大多数食物纤维含量的数据，对这一假说的流行病学研究受到了阻碍。在斯堪的纳维亚半岛和英国，人们使用精确的方法测量了膳食纤维的主要化学成分——非淀粉多糖的摄入量，结果显示其与结肠癌的发生呈显著负相关。这些研究表明，对于那些因过多摄入肉类和脂肪而患结肠癌风险较高的人群，非淀粉多糖可能具有保护作用。然而，个体非淀粉多糖摄入量评估中的方法学问题使得无法通过病例对照研究在单一同质人群中验证这些关联。
