Bingham S A
Med Oncol Tumor Pharmacother. 1985;2(3):149-55. doi: 10.1007/BF02934542.
The hypothesis that lack of fibre in the diet is responsible for a variety of large bowel problems, including cancer, has stimulated much discussion and research over the past 15 years. However, the epidemiological examination of this hypothesis has been hampered by the absence of data on the fibre content of most of the world's foods. In studies in Britain and Scandinavia where consumption of the chemical fraction of dietary fibre, the non-starch polysaccharides, has been determined using accurate methods, significant negative association between colon cancer occurrence and NSP consumption have been shown. Fibre may therefore be protective to populations otherwise assumed to be at risk from a westernised type of diet. At present, methodological problems preclude the use of case-control studies in confirming or refuting these associations.
饮食中缺乏纤维是包括癌症在内的多种大肠疾病的病因，这一假说在过去15年里引发了诸多讨论和研究。然而，由于缺乏世界上大多数食物纤维含量的数据，这一假说的流行病学检验受到了阻碍。在英国和斯堪的纳维亚进行的研究中，使用精确方法测定了膳食纤维的化学成分即非淀粉多糖的摄入量，结果显示结肠癌发生率与非淀粉多糖摄入量之间存在显著的负相关。因此，纤维可能对那些原本被认为有西式饮食风险的人群具有保护作用。目前，方法学问题使得无法通过病例对照研究来证实或反驳这些关联。
