Maclennan R, Jensen O M
Lancet. 1977 Jul 30;2(8031):207-11.
A comparison of dietary intake and faecal characteristics in population samples from two areas of Denmark and Finland with 4-fold variation in colon-cancer incidence suggests that the aetiology of colon cancer may be multifactorial and is not associated in a simple manner with dietary fat, neutral steroids, acid steroids, or their bacterial metabolites. However, meat consumption was greater in the high-incidence areas. Higher intakes of dietary fibre and milk in the low-incidence area suggest a possible protective effect, unrelated to mouth-anus transit-time. Further careful dietary and metabolic studies are needed to clarify the relationships between possible carcinogenic and protective effects of diet.
对丹麦和芬兰两个地区人群样本的饮食摄入与粪便特征进行比较，这两个地区结肠癌发病率相差4倍，结果表明结肠癌的病因可能是多因素的，与膳食脂肪、中性类固醇、酸性类固醇或其细菌代谢产物并无简单关联。然而，高发病率地区的肉类消费量更大。低发病率地区膳食纤维和牛奶的摄入量较高，这表明可能存在一种保护作用，与口腔至肛门的转运时间无关。需要进一步进行细致的饮食和代谢研究，以阐明饮食可能的致癌作用与保护作用之间的关系。
