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1型单纯疱疹病毒基因组中包含核酸外切酶基因及相邻基因的区域的DNA序列。

DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.

作者信息

McGeoch D J, Dolan A, Frame M C

出版信息

Nucleic Acids Res. 1986 Apr 25;14(8):3435-48. doi: 10.1093/nar/14.8.3435.

DOI:10.1093/nar/14.8.3435
PMID:3010237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC339783/
Abstract

We report the sequence of a 7800 base pair region of herpes simplex virus type 1 DNA, representing approximately 0.16 to 0.20 map units in the genome. This contains sequences transcribed into a leftward oriented set of five 3' coterminal mRNAs, together with two rightward transcribed flanking genes. One of the leftward genes encodes the virus's alkaline exonuclease, but the other gene products are uncharacterized. The amino acid sequence of one encoded protein suggested that it is a membrane embedded species. The DNA sequence is densely utilised, with two predicted out-of-frame overlaps of coding sequences, and probably six occurrences of promoter elements within coding sequences. Homologues of five of the genes were found for the distantly related Epstein-Barr virus, with a similar overall relative arrangement.

摘要

我们报道了单纯疱疹病毒1型DNA的一个7800碱基对区域的序列，该区域在基因组中约占0.16至0.20个图距单位。它包含转录成一组五个3' 共末端左向mRNA的序列，以及两个右向转录的侧翼基因。其中一个左向基因编码病毒的碱性核酸外切酶，但其他基因产物尚未明确。一种编码蛋白的氨基酸序列表明它是一种膜嵌入蛋白。该DNA序列被高度利用，有两个预测的编码序列框外重叠，并且编码序列内可能有六个启动子元件出现。在远亲的爱泼斯坦-巴尔病毒中发现了其中五个基因的同源物，其总体相对排列相似。

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DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.1型单纯疱疹病毒基因组中包含核酸外切酶基因及相邻基因的区域的DNA序列。
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本文引用的文献

1
Acquisition of thymidine kinase activity by herpes simplex-infected mouse fibroblast cells.单纯疱疹感染的小鼠成纤维细胞获得胸苷激酶活性。
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Codon preference and its use in identifying protein coding regions in long DNA sequences.密码子偏好性及其在长DNA序列中识别蛋白质编码区的应用。
Nucleic Acids Res. 1982 Jan 11;10(1):141-56. doi: 10.1093/nar/10.1.141.
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A fast homology program for aligning biological sequences.一种用于比对生物序列的快速同源性程序。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):447-55. doi: 10.1093/nar/12.1part2.447.
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A comprehensive set of sequence analysis programs for the VAX.一套适用于VAX的综合序列分析程序。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95. doi: 10.1093/nar/12.1part1.387.
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Homology between two EBV early genes and HSV ribonucleotide reductase and 38K genes.两种EBV早期基因与HSV核糖核苷酸还原酶及38K基因之间的同源性。
Nucleic Acids Res. 1984 Jun 25;12(12):5087-99. doi: 10.1093/nar/12.12.5087.
7
A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence.来自单纯疱疹病毒1型短区域的一个3' 共末端mRNA家族：两个重叠阅读框编码不相关的多肽，其中一个具有高度重复的氨基酸序列。
Nucleic Acids Res. 1984 Mar 12;12(5):2473-87. doi: 10.1093/nar/12.5.2473.
8
Fragments from both termini of the herpes simplex virus type 1 genome contain signals required for the encapsidation of viral DNA.单纯疱疹病毒1型基因组两端的片段含有病毒DNA包装所需的信号。
Nucleic Acids Res. 1983 Dec 10;11(23):8205-20. doi: 10.1093/nar/11.23.8205.
9
Characterization of the TRS/IRS origin of DNA replication of herpes simplex virus type 1.单纯疱疹病毒1型DNA复制的TRS/IRS起始位点的特性分析
Virology. 1983 Oct 30;130(2):427-38. doi: 10.1016/0042-6822(83)90097-1.
10
DNA sequence elements required for regulated expression of the HSV-1 glycoprotein D gene lie within 83 bp of the RNA capsites.单纯疱疹病毒1型糖蛋白D基因的调控表达所需的DNA序列元件位于RNA帽位点的83个碱基对范围内。
Nucleic Acids Res. 1983 Oct 11;11(19):6647-66. doi: 10.1093/nar/11.19.6647.