1型单纯疱疹病毒基因组中包含核酸外切酶基因及相邻基因的区域的DNA序列。
DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.
作者信息
McGeoch D J, Dolan A, Frame M C
出版信息
Nucleic Acids Res. 1986 Apr 25;14(8):3435-48. doi: 10.1093/nar/14.8.3435.
Abstract
We report the sequence of a 7800 base pair region of herpes simplex virus type 1 DNA, representing approximately 0.16 to 0.20 map units in the genome. This contains sequences transcribed into a leftward oriented set of five 3' coterminal mRNAs, together with two rightward transcribed flanking genes. One of the leftward genes encodes the virus's alkaline exonuclease, but the other gene products are uncharacterized. The amino acid sequence of one encoded protein suggested that it is a membrane embedded species. The DNA sequence is densely utilised, with two predicted out-of-frame overlaps of coding sequences, and probably six occurrences of promoter elements within coding sequences. Homologues of five of the genes were found for the distantly related Epstein-Barr virus, with a similar overall relative arrangement.
摘要
我们报道了单纯疱疹病毒1型DNA的一个7800碱基对区域的序列，该区域在基因组中约占0.16至0.20个图距单位。它包含转录成一组五个3' 共末端左向mRNA的序列，以及两个右向转录的侧翼基因。其中一个左向基因编码病毒的碱性核酸外切酶，但其他基因产物尚未明确。一种编码蛋白的氨基酸序列表明它是一种膜嵌入蛋白。该DNA序列被高度利用，有两个预测的编码序列框外重叠，并且编码序列内可能有六个启动子元件出现。在远亲的爱泼斯坦-巴尔病毒中发现了其中五个基因的同源物，其总体相对排列相似。
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本文引用的文献
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Acquisition of thymidine kinase activity by herpes simplex-infected mouse fibroblast cells.单纯疱疹感染的小鼠成纤维细胞获得胸苷激酶活性。
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A comprehensive set of sequence analysis programs for the VAX.一套适用于VAX的综合序列分析程序。
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