Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, The Netherlands.
Department of Radiology and Nuclear Medicine, Radboud University Medical Center, The Netherlands.
J Neuromuscul Dis. 2018;5(3):315-319. doi: 10.3233/JND-180318.
Sampling error is a common problem in muscle biopsies. MRI-guided biopsy allows verification of biopsy site during the procedure, which may reduce sampling error in patients with focal disease.
To describe the technique for MRI-guided muscle biopsy and discuss potential applications.
Axial MRI images were acquired to determine the target site for muscle biopsy. Needle trajectory was planned on 3D T1 weighted imaging and a MRI-guided biopsy of the vastus lateralis was performed in 13 FSHD patients.
An adequate amount of muscle tissue was obtained in all participants, and MRI-guided biopsy succeeded in reaching focal target sites. However, symptomatic hematomas were observed in 2/13 patientsDiscussion:MRI-guided biopsy has a higher complication rate compared to traditional needle biopsy, most likely due to proximity to blood vessels in combination with the vacuum-assisted suction of the MRI-guided technique. We recommend that this technique is reserved for select diagnostic cases and research questions, with careful assessment of vasculature and reduced suction levels.
抽样误差是肌肉活检中常见的问题。MRI 引导下的活检可在手术过程中验证活检部位，从而减少局灶性疾病患者的抽样误差。
描述 MRI 引导下肌肉活检的技术并讨论其潜在应用。
采集轴位 MRI 图像以确定肌肉活检的目标部位。在 3D T1 加权成像上规划针道，对 13 例 FSHD 患者行股外侧肌 MRI 引导下活检。
所有参与者均获得了足够量的肌肉组织，MRI 引导下活检成功到达了局灶性目标部位。然而，2/13 例患者出现症状性血肿。
与传统的针活检相比，MRI 引导下活检的并发症发生率更高，这很可能是由于靠近血管，再加上 MRI 引导技术的真空抽吸作用。我们建议将该技术保留用于特定的诊断病例和研究问题，并仔细评估血管和降低抽吸水平。
