García-Sevilla J A, Ulibarri I, Giralt M T, Areso P, Oliveros R G, Gutiérrez M
Department of Pharmacology, Faculty of Medicine, University of the Basque Country, Leioa.
J Neural Transm. 1988;73(2):157-60. doi: 10.1007/BF01243386.
Naltrexone, an opioid receptor antagonist, is used as an adjunct in the treatment of opiate addiction. In former heroin addicts, long-term treatment with naltrexone (350 mg/week for 5 months) resulted in suppression of adrenaline and 5-hydroxytryptamine (5-HT)-induced platelet aggregation. The results demonstrate that sustained blockade of opioid receptors can impair the functional expression of alpha 2-adrenoceptors and 5-HT2 receptors in human platelets. These findings may have negative clinical implications in the treatment of opiate addiction with naltrexone.
纳曲酮是一种阿片受体拮抗剂，用作治疗阿片成瘾的辅助药物。在既往海洛因成瘾者中，长期使用纳曲酮治疗（350毫克/周，持续5个月）导致肾上腺素和5-羟色胺（5-HT）诱导的血小板聚集受到抑制。结果表明，阿片受体的持续阻断会损害人血小板中α2-肾上腺素能受体和5-HT2受体的功能表达。这些发现可能对纳曲酮治疗阿片成瘾具有负面临床意义。
