苯并喹喔啉氟喹诺酮类左氧氟沙星（WCK 771）和其他抗菌药物对人类支原体和脲原体的活性，包括具有明确耐药机制的分离株。
Activities of the Benzoquinolizine Fluoroquinolone Levonadifloxacin (WCK 771) and Other Antimicrobial Agents against Mycoplasmas and Ureaplasmas in Humans, Including Isolates with Defined Resistance Mechanisms.
机构信息
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Bacteriology, Capital Institute of Pediatrics, Beijing, China.
出版信息
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01348-18. Print 2018 Nov.
Abstract
Levonadifloxacin (WCK 771) was evaluated against 68 type strains and clinical isolates of , , , and spp. in comparison with moxifloxacin, levofloxacin, tetracycline, and azithromycin or clindamycin. Levonadifloxacin MICs were ≤0.5 μg/ml for MICs were 1 μg/ml for , 0.125 μg/ml for , and 2 μg/ml for spp. Levonadifloxacin merits further study for treating infections caused by these organisms.
摘要
左氧氟沙星（WCK771）与莫西沙星、左氧氟沙星、四环素、阿奇霉素或克林霉素进行比较，对 、 、 和 属 68 种标准株和临床分离株进行了评估。左氧氟沙星的 MICs 均≤0.5 μg/ml， 的 MICs 为 1 μg/ml， 的 MICs 为 0.125 μg/ml， 的 MICs 为 2 μg/ml。左氧氟沙星值得进一步研究，以治疗这些病原体引起的感染。
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