Department of Neurology, Kashan University of Medical Sciences, Kashan, Iran.
Halal Research Center of IRI, FDA, Tehran, Iran.
Metab Brain Dis. 2018 Dec;33(6):1955-1959. doi: 10.1007/s11011-018-0302-7. Epub 2018 Aug 13.
Different immune-mediated mechanisms involved in the pathogenesis of Parkinson disease (PD) as a neurodegenerative and inflammatory disease. According to our knowledge, there is no report evaluating Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2), a cytokine maintaining immune homeostasis, in PD. We analyzed the correlation of the serum levels and circulatory gene expression of TIPE2 with severity of PD. In this case-control study, 43 patients with PD and 40 healthy subjects were enrolled. The diagnosis of PD was performed byclinical diagnostic criteria of the UK Parkinson's Disease Society Brain Bank. The severity of PD was evaluated by modified Hoehn and Yahr (H and Y) scale. Serum levels and gene expression of TIPE2 were assessed by Elisa and real time PCR, respectively. The mean serum levels and gene expression of TIPE2 in patients with PD did not have significant difference compared to healthy subjects. Linear multiple regression analysis showed that increased serum levels of TIPE2 are positively related to age and severity of PD (P ≤ 0.0001). In addition, the gene expression of TIPE2 was found to be associated with age (P < 0.0001). Our study showed that the serum levels of TIPE2 and its gene expression might be important prognostic biomarkers of PD.
不同的免疫介导机制参与了帕金森病 (PD) 的发病机制，PD 是一种神经退行性和炎症性疾病。据我们所知，目前尚无关于细胞因子维持免疫稳态的肿瘤坏死因子-α诱导蛋白-8 样蛋白 2（TIPE2）在 PD 中的评估报告。我们分析了 TIPE2 的血清水平和循环基因表达与 PD 严重程度的相关性。在这项病例对照研究中，纳入了 43 名 PD 患者和 40 名健康对照者。PD 的诊断通过英国帕金森病学会脑库的临床诊断标准进行。PD 的严重程度通过改良 Hoehn 和 Yahr（H 和 Y）量表进行评估。TIPE2 的血清水平和基因表达分别通过 Elisa 和实时 PCR 进行评估。与健康对照组相比，PD 患者的 TIPE2 血清水平和基因表达均无显著差异。线性多元回归分析显示，TIPE2 血清水平升高与年龄和 PD 严重程度呈正相关（P≤0.0001）。此外，TIPE2 的基因表达与年龄相关（P<0.0001）。我们的研究表明，TIPE2 的血清水平及其基因表达可能是 PD 的重要预后生物标志物。
