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[低温时大脑的ATP酶和乙酰胆碱酯酶活性]

[ATPase and acetylcholinesterase activity of the brain in hypothermia].

作者信息

Emirbekov E Z, Klichkhanov N K

出版信息

Vopr Med Khim. 1986 Mar-Apr;32(2):32-4.

PMID:3010568
Abstract

Short-term hypothermia, caused by cooling of rats down to 20 degrees, decreased distinctly the Na+, K+-ATPase activity in brain homogenates incubated at 37 degrees and did not affect the enzyme activity in the homogenates incubated at 20 degrees. The longer hypothermia (2 hrs at 20 degrees) did not affect the Na+, K+-ATPase activity at 37 degrees (during incubation) and decreased the enzymatic activity in homogenates of middle brain and diencephalon at 20 degrees during the incubation. Contrary to Na+, K+-ATPase, the activity of acetylcholinesterase was markedly increased in brain tissues of rats with hypothermia (irrespective of the temperature of incubation) as compared with control animals.

摘要

将大鼠体温降至20度所导致的短期低温,显著降低了在37度孵育的脑匀浆中的钠钾ATP酶活性,而对在20度孵育的匀浆中的酶活性没有影响。较长时间的低温(20度下2小时)对37度(孵育期间)的钠钾ATP酶活性没有影响,但在孵育期间降低了中脑和间脑在20度时匀浆中的酶活性。与钠钾ATP酶相反,与对照动物相比,低温大鼠脑组织中的乙酰胆碱酯酶活性显著增加(无论孵育温度如何)。

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