Kälebo P, Jacobsson M, Albrektsson T, Turesson I
Acta Oncol. 1987 Jan-Feb;26(1):63-8. doi: 10.3109/02841868709092980.
The bone harvest chamber (BHC) methodology, a titanium implant for quantitative evaluations of bone healing, was used in order to investigate the radioprotective function of anoxia, in healing bone tissue. After incorporation of one BHC in each proximal tibial metaphysis of a rabbit it was possible to collect newly formed bone specimens in 3-week-periods without animal sacrifice. The amount of bone was determined by microradiography and densitometry. Ten animals divided into 2 groups were used. One group receiving a single dose of 25 Gy during tourniquet ischaemia was compared with another receiving the same dose during normal blood perfusion. A significantly improved bone healing response was seen in the ischaemic group, with a tendency to further improvement with increasing time after irradiation.
骨采集室（BHC）方法是一种用于定量评估骨愈合的钛植入物，为研究缺氧在愈合骨组织中的辐射防护功能，在每只兔子的近端胫骨干骺端植入一个BHC。这样就可以在3周的时间段内收集新形成的骨标本，而无需牺牲动物。通过显微放射照相术和密度测定法确定骨量。使用了10只动物，分为2组。一组在止血带缺血期间接受单次25 Gy剂量照射，与另一组在正常血液灌注期间接受相同剂量照射进行比较。缺血组的骨愈合反应明显改善，且随着照射后时间的增加有进一步改善的趋势。
